Daily

Which parameter must be monitored in a patient taking ambrisentan?

Ambrisentan is an endothelin receptor antagonist that may cause hepatotoxicity with prolonged use. Therefore liver function tests should be performed every month on the patient receiving the medication. Serum and urine electrolytes are analyzed in the patient with cor pulmonale to evaluate the sodium level.

When to avoid taking ambrisentan in severe impairment? Manufacturer advises avoid—no information available. Manufacturer advises avoid in severe impairment or if baseline serum transaminases exceed 3 times the upper limit of normal. Use with caution if creatinine clearance less than 30 mL/minute.

How does ambrisentan work for people with PAH? Ambrisentan may improve the ability to exercise and slow the worsening of symptoms in people with PAH. Ambrisentan is in a class of medications called endothelin receptor antagonists. It works by stopping the action of endothelin, a natural substance that causes blood vessels to narrow and prevents normal blood flow in people who have PAH.

Is it safe to take ambrisentan if you are pregnant? Ambrisentan may harm the fetus. If you are a woman and able to become pregnant, you should not begin taking ambrisentan until a pregnancy test has shown that you are not pregnant. You must use two reliable methods of birth control during treatment with this medication and for 1 month after stopping treatment.

What’s the best way to take ambrisentan tablets? Take ambrisentan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow the tablets whole; do not split, chew, or crush them. Your doctor may start you on a low dose of ambrisentan and gradually increase your dose.

How often can you increase the dose of ambrisentan?

How often can you increase the dose of ambrisentan? At 4-week intervals, either ambrisentan or tadalafil dose can be increased, as needed and tolerated, not to exceed ambrisentan 10 mg/day or tadalafil 40 mg/day.

What to do if you miss your period while taking ambrisentan? Call your doctor immediately if you miss a menstrual period or think you may be pregnant while you are taking ambrisentan. Because of the risk of birth defects, ambrisentan is available to females only through a special restricted distribution program.

Is it safe to take ambrisentan if you are pregnant? Ambrisentan may harm the fetus. If you are a woman and able to become pregnant, you should not begin taking ambrisentan until a pregnancy test has shown that you are not pregnant. You must use two reliable methods of birth control during treatment with this medication and for 1 month after stopping treatment.

What are the effects of ambrisentan on apalutamide? Use Caution/Monitor. Apalutamide weakly induces OATP1B1 and may decrease systemic exposure of drugs that are OATP1B1 substrates. ambrisentan will increase the level or effect of bazedoxifene/conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.