Daily

Which is better amlodipine or irbesartan?

The main finding of this randomized, controlled study in hypertensive patients with echocardiographically-determined LVH is that irbesartan appears to be more effective than amlodipine in reducing LVMI after 6 months of treatment, despite a similar effect on BP of the two drugs.

Which is better amlodipine or irbesartan after 3 months? After 3 months, echocardiographically estimated LVMI decreased by 23.2% in the irbesartan-treated patients and 11.4% in the amlodipine-treated patients, with an adjusted mean difference of 11.8% in favor of irbesartan ( P < 0.0001).

What are the side effects of amlodipine and losartan? See the full amlodipine side effects document. Commonly reported side effects include: asthenia, chest pain, diarrhea, fatigue, and hypoglycemia. See the full losartan side effects document. The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

When to take amlodipine before or after randomization? Before randomization (common with other arms): There is an initial washout (placebo run-in) period of 2 weeks for subjects already on anti-hypertensive monotherapy. After randomization: 8 weeks of treatment with Irbesartan 300 mg / Amlodipine 5 mg once a day. Drug: Irbesartan / Amlodipine.

What are the secondary objectives of the irbesartan study? The secondary objectives are: to compare the reduction of mean Seated Systolic Blood Pressure (SeSBP) at the end of 8 weeks from baseline between each FDC, its individual constituents administered as monotherapy and placebo.

When to increase the dose of amlodipine or irbesartan?

When to increase the dose of amlodipine or irbesartan? Dosage of both drugs was increased to irbesartan 300 mg once daily or amlodipine 10 mg once daily in case of sitting diastolic BP still >90 mm Hg after the first 2 weeks of treatment. Dosage doubling was necessary in more than 50% of patients in both treatment groups.

Which is better amlodipine or irbesartan for LV Edd? Irbesartan was also superior to amlodipine in decreasing PW thickness, both after 3 months (adjusted mean difference, −14.3% vs. −6.9%; P < 0.0001) and 6 months of treatment (adjusted mean difference, −15.2% vs. −7.9%; P < 0.0001). By contrast, LV EDD remained virtually unchanged in irbesartan and amlodipine treatments.

When to take amlodipine before or after randomization? Before randomization (common with other arms): There is an initial washout (placebo run-in) period of 2 weeks for subjects already on anti-hypertensive monotherapy. After randomization: 8 weeks of treatment with Irbesartan 300 mg / Amlodipine 5 mg once a day. Drug: Irbesartan / Amlodipine.

What are the secondary objectives of the irbesartan study? The secondary objectives are: to compare the reduction of mean Seated Systolic Blood Pressure (SeSBP) at the end of 8 weeks from baseline between each FDC, its individual constituents administered as monotherapy and placebo.