What pain reliever can i take with trazodone?

Are you tired of living in pain but also taking trazodone for your anxiety? Fear not, my friend! There are options available to ease your discomfort without risking any nasty drug interactions.

But before we dive into those, let’s take a quick look at what exactly trazodone is and why it’s important to be cautious when mixing medications.

Trazodone: A Brief Overview

Trazodone falls under the category of antidepressant medications known as Serotonin Reuptake Inhibitors (SSRIs). SSRIs work by restoring balance to certain chemicals in the brain that affect mood such as serotonin. However, trazodone differs from most other SSRIs since its primary use isn’t for treating depression but rather used off-label widely among psychiatrists and physicians alike due to its sedative properties which help with insomnia resulting from anxiety or depression.

Now that we know a little more about trazodone let’s talk about some common medications that can hand-in-hand with it without causing problems.

Safe Pain Relievers For Use With Trazadone

  1. Acetaminophen: This mild pain reliever popularly marketed under brand names such as Tylenol™ or Panadol™ has been one of the preferred NSAID-free go-to options by medical practitioners worldwide when patients are seeking relief from mild-moderate pain.

  2. Aspirin (with discretion): Also known as acetylsalicylic acid; low doses (81mg) have been approved to mitigate heart attack risks alongside antiplatelet action thus deter blood clotting while high dosages effective for moderate pain management provided they won’t interfere with another medication patient might already be on – told you discretion matters!

  3. Naproxen/Piroxicam/Indomethacin: These are some of the commonly prescribed NSAIDs used for management of acute and chronic pain conditions, but should always be taken with caution if you’re taking anticoagulants concurrently since they have an increased risk of bleeding.

  4. Codeine (with discretion): This is a narcotic pain reliever that requires a prescription, so it’s important to discuss your options carefully before taking this medication. Some common side-effects associated with using this include drowsiness, constipation or altered mental alertness.

It’s vital never to forget even herbal remedies such as kava can interact negatively with trazodone hence utmost care must be exercised when following multiple treatment regimens concurrently!

Safe Dosages

Now that we’ve established which types of pain relievers can be mixed safely with trazodone let’s consider how much is too much.

The recommended maximum daily dose limit for non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen and naproxen stands at 3200mg per day while acetaminophen maximum dosage shouldn’t exceed 4000mg daily – Clearly exceeding these amounts has been shown in various health studies to potentially trigger irreversible drug-induced toxicity to many organs including liver or kidneys leading either partial failure or organ shutdown entirely and hence extreme care must be practiced by patients seeking instant relief from any ailment(s).

What To Do If You Experience Side Effects?

Despite trying out all safety measures highlighted above one may still encounter unintended reactions after starting Trazodrone-eased sessions/schedules especially if there was already ongoing use of other related medications. Adverse events arising from such combinations require immediate medical attention therefore medical intervention under emergencies becomes necessary In cases where adverse effects experienced; it critically paramount contacting private physicians/local emergency services right away don’t just wait things won’t get better on their own!


In conclusion, finding the right pain reliever to use in conjunction with trazodone is important, but it’s not without its challenges. Always consult your healthcare professional about mixing medication and familiarize yourself with safe dosages and possible side effects when taking them. With careful planning though, you can enjoy relief from pain without risking drug interactions – Whether it’s a mild headache or severe pain there are options out there so don’t suffer one minute longer.

With that said, I hope this guide has been helpful to anyone who needed clarity on what medications they could safely take while using Trazodone!