What mutation causes alzheimer’s?

Alzheimer’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide. While the exact cause of this debilitating condition remains unknown, researchers have identified several genetic mutations that are associated with an increased risk for developing Alzheimer’s.

In this article, we’ll delve into the wonderfully wacky world of Alzheimer’s mutation and explore some of the weirdest and wildest research findings on this topic.

Mutations: What Are They Good For? Absolutely Nothing!

To understand what causes Alzheimer’s disease at the molecular level, we need to take a closer look at DNA, which contains all the instructions necessary to build and maintain our bodies.

DNA (deoxyribonucleic acid) consists of four types of chemical units called nucleotides: adenine (A), guanine (G), cytosine (C) and thymine(T). These letters can be arranged in different ways to form unique sequences that determine how genes are turned on or off in cells throughout our body.

Mutations, simply put, occur when mistakes happen during DNA replication causing changes in these letters’ sequence. Sometimes these random alterations could make us superheroes like Wolverine from X-Men who healed himself rapidly or other times end up giving us gallstones!

A Beta Problem

One famous genetic mutation linked to early-onset familial/inherited Alzheimer’s is APP gene AD-3 variant. This faulty APP gene has also been found present but impaired in sporadic late onset cases as well Imagine being born with beta amyloid protein seeping out from your brain!!! Gross!

The amyloid-beta proteins involved with AD start long before plaques accumulate around neurons impairing synapses When communication between adjacent neurons fails there will be no chance left for you bossing everyone around like Miranda Priestly

Although specifically inside neuronal connections happens detrimentally initially; eventually even touching upon the direct cellular function.

Proteins Behaving Badly

Another genetic mutation associated with Alzheimer’s is a variant of the PSEN1 gene, which encodes an enzyme called presenilin-1. This enzyme is involved in processing amyloid precursor protein (APP), which plays a crucial role in the formation and maintenance of synapses – basically how neurons communicate with one another.

People with mutations in this particular gene have abnormal folding issues leading to creases that do not sit well within surrounding environmental organelles during development disturbing brain functions involving cognition impairment early on as they may present diseases such as Downs syndrome or be prone to dementia later on.

Build-A-Brain Workshop

Recent research has shown that multiple genetic factors interact with lifestyle related risk factors contributing towards AD pathology via Tau & Beta amyloid deposits buildup Consider your family history like forces shaping various blocks placed into your mental Rubik’s cube; some making it worse than others!

Now better equipped researchers are prefabricating lab-grown miniaturized human brains allowing them more insight into underlying processes events accumulation occasions aiding them toward brighter hope for cure finding avenues for future generations!

Our increasingly advanced and detailed understanding of these mutations paves the way for targeted treatments against Alzheimer’s disease, which could potentially offer relief to millions of people suffering from this devastating condition. While there may still be much we don’t know about this disorder, we can rest assured that scientists will continue working around the clock to unravel its secrets – maybe even solve what causes AD once they’ve figured out why pandas’ fur color scheme is so confusing!

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