What medications does vitamin d interfere with?

You might think that vitamin D, the beloved sunshine vitamin, only interacts with other vitamins or supplements. However, it turns out that certain medications can have a significant impact on how much vitamin D your body receives and processes. In this article, we’ll take a closer look at some of the medications that can interfere with your body’s ability to make use of its favorite vitamin.

A Brief Introduction to Vitamin D

Before we dive into the world of drug interactions, let’s start by revising our understanding of what exactly is Vitamin D. Did you know that it belongs in the group of fat-soluble vitamins? It means it dissolves in fats and oils rather than water-based liquids like juice or soda.

When ultraviolet light from the sun penetrates your skin cells, these cells convert cholesterol into cholecalciferol (vitamin D3). The liver then converts cholecalciferol into calcidiol(C_25H_42O), which circulates throughout the bloodstream Long story short, after undergoing additional processing by 1-alpha-hydroxylase enzymes – also called CYP27B1 – calcidiol becomes activated as calcitriol(C27H44O3) . Now you may be asking yourself: ‘Why do I care about all this technical terminology?’ Our answer – Understanding more about VitD’s metabolic journey will help us unpack how various drugs interact with different stages of its bioavailability process.

So without further ado,

What Meds Can Mess With My Levels Of This Magic Vitamin?


What does Cholestyramine sound like to you? Maybe a fancy name for ice cream flavor perhaps…
But unfortunately friends- Cholestyramine isn’t something sweet! In fact,Cholestryamine is’nt even human digestion-friendly. This drug is known as a bile acid-binding resin, which means it helps your body eliminate certain types of fats that the liver produces in its healthy state.
Cholestyramine can also interfere with vitamin D absorption and metabolism by preventing vitamin D from reaching your intestines
Meanwhile – this interruption results in fecal loss of Vitamin D – And we all know where THAT leads to right? Let’s just say you won’t be able to get into those new jeans you bought if Cholestyramine becomes part of your diet regimen.


Orlitstat may sound like some space-powered tech gadget or perhaps an exotic bird found only on remote islands across the globe but nope! Sorry not sorry- none of that here friends! We’re talking about a weight-loss medication marketed under-the-counter. This medication blocks intestinal lipases, responsible for breaking down fat molecules, So naturally Orlitstad will cause fewer fats to make their way through digestion and into the bloodstream.
Unfortunately though taking Orlistat isn’t great news for those trying hard to keep up with VitD intake because again; blocked lipid/fat breakdown process equals blocked Vitamin-D Hydrolysis!!!!!! Therefore Interfering VItD abosrption!.


Say hello to one of our ancient yet well-known ‘friends’- phenobarBITAL.. I mean who hasn’t heard about this anti-seizure treatment back from grandpappy days? Unfortunately though, Phenobarbital isn’t best buddies with VtD unlike its friendship ties over centuries with Epileptic patients out there. From hindering CTD26-b1 production enzymes (essential for converting calcidiol(calcifediol) 25-hydroxyvitamin |(OH)Vitamin ]2[C] into usable calcitriol form^11 & decreased renal 24 hyroxylase activity (that is, ensuring excess VitD is eliminated through the kidneys), Phenobarbital tends to amplify exerts metabolic pressure on biologically essential regulatory processes but it’s fair warning?


Diphenyl-hy-what? This tongue-twisted drug name first discovered in 1908 has since become quite popular as an anticonvulsant medication. Nonetheless, It too interacts unfavourably with the bioavailability of vitamin D by Depressing host CYP27B1 enz production especially when combined with phenobarbital^33.

In Conclusion

As you can see, a number of medications may interact negatively with Vitamin D availability and metabolism. Those who regularly take things like cholestyramine, orlistat, phenobarbital and diphenylhydantoins should be particularly cautious about their VitD intake & processing abilities .

While some drugs might not cause much harm for those who get enough sunlight exposure , others above will most certainly make it hard for your body to fulfill its absorption needs via nutrients alone… As such interactions predispose one either deficient or worse off with Hypervitaminosis D! So if you’re planning on taking any of these medications anytime soon do remember that seeking medical advice can help guide optimal outcome towards achieving good therapeutic response!

Disclaimer: The above article only serves informational purposes only! Please consult health care specialists before starting or discontinuing any medication(s).

Random Posts