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What is the half life of adenosine?

Adenosine monophosphate formed by phosphorylation of Adenosine is incorporated into the high-energy phosphate pool. While extracellular Adenosine is primarily cleared by cellular uptake with a half-life of less than 10 seconds in whole blood, excessive amounts may be deaminated by an ecto-form of Adenosine deaminase.

What is the half life of adenosine in the heart? Sometimes the reduction of electrical activity at the AV node can cause AV block. Adenosine has a very short half-life (less than 10 seconds) so the effects slow down the heart enough to reset the electrical rhythm back to normal sinus rhythm.

How long does it take for adenosine to metabolize? The half-life of adenosine is less than 10 seconds and so the adenosine would be completely metabolized within a maximum time of 30 seconds. It would seem logical that a second dose could be given after 30-60 seconds, but the guidelines clearly state that it may be repeated after 1-2 minutes.

How is adenosine broken down in red blood cells? Most importantly, adenosine is rapidly transported into red blood cells (and other cell types) where it is rapidly deaminated by adenosine deaminase to inosine, which is further broken down to hypoxanthine, xanthine and uric acid, which is excreted by the kidneys.

What are the most common side effects of adenosine? The most common (incidence ≥ 10%) adverse reactions to Adenosine are flushing, chest discomfort, shortness of breath, headache, throat, neck or jaw discomfort, gastrointestinal discomfort, and dizziness (Table 2). Adverse reactions to Adenosine of any severity reported in less than 1% of patients include:

What is the half life of adenosine in plasma?

What is the half life of adenosine in plasma? The half-life of this initial phase is approximately 2 to 4 minutes. An intermediate phase follows with an average half-life of 30 minutes coinciding with loss of the pharmacodynamic effect. The last phase consists of a decline in plasma con- centration with a half-life of approximately 2 hours.

What does adenosine do to the human heart? Adenosine is a naturally occurring substance that relaxes and dilates blood vessels. Adenosine also affects the electrical activity of the heart. Adenosine is used to help restore normal heartbeats in people with certain heart rhythm disorders.

When do the side effects of adenosine go away? Due to the short half-life of adenosine (<10 seconds), most side effects resolve in a few seconds after discontinu- ation of the adenosine infusion. However, the occasional patient may require administration of aminophylline for reversal of persistent symptoms.

How long does it take for adenosine to metabolize? The half-life of adenosine is less than 10 seconds and so the adenosine would be completely metabolized within a maximum time of 30 seconds. It would seem logical that a second dose could be given after 30-60 seconds, but the guidelines clearly state that it may be repeated after 1-2 minutes.