What is mixed hyperlipidemia mean?
Mixed hyperlipidemia, also known as dysbetalipoproteinemia or type III hyperlipoproteinemia, sounds like a term invented by Bart Simpson for his next prank call to Moe’s Tavern. However, it’s actually a very real condition that affects people all around the world. In this article, we’ll take a deep dive into mixed hyperlipidemia, what it means for your health, and how you can manage it.
Let’s start with some basics
First things first: what exactly is hyperlipidemia?
Hyperlipidemia refers to high levels of lipids (fats) in your blood. There are five major types of lipids:
- Free fatty acids
Now let’s address why having these lipids in our bodies could pose a problem.
Elevated levels of certain types of lipids can contribute to developing coronary artery disease (CAD). CAD occurs when plaque builds up inside the arteries leading to the heart muscle which leads to blockages or narrowing of the coronary arteries and thus restricts blood supply that carries oxygen and nutrients to heart muscles.
Before you start panicking though – did you know that not all cholesterol is bad? There are two main types:
- High-density lipoproteins (HDL), which remove extra LDL from circulation.
- Low-density lipoproteins (LDL), which deposit cholesterol into arterial walls.
Like many things in life–it’s complicated!
The Mix-Up That Is Mixed Hyperlipidemia
So now we have established what regular ol’ hyperlidipemoaia is… but then there’s mixed-type like dysbetalipoproteinema! Explain please?
In short: mixed hyperlipidemia is a condition where there are abnormal levels of different lipids in your blood, specifically cholesterol and triglycerides. It’s not as simple as having too much LDL – it’s an intermingling of things like IDL particles along with unprocessed chylomicrons that create remnant-like particles.
If you have mixed hyperlipidemia, your liver has difficulties processing normal-rich VLDL or very-low-density lipoprotein. Which leads to the build-up of harmful substances known as intermediate-density lipoprotein (IDL) cholesterol and also residual chylomicron remnants–sometimes all lumped together and called beta-VLDL.
Now that sounds confusing; let’s break this down:
- Very low density lipoproteins (VLDL) transport endogenous triacylglycerol
- When extra weight accumulates along the way leading to altered xanthophyll esters formations from hydroxy methyl glutaryl CoA reductase conversion leading to formation:
- Intermediate-density’ Lipoproetein(IDL)
- Remnant Like Particle(RLP)
Also seen are increased amounts in genetic variations promoting apolipoprotien E3 alleys impeding on hepatic recognition cells lacking specialized receptors (leading to overproduction).
Stay with me here because we’re going even deeper!
Who is at risk?
First off, let’s answer who it affects: about 5% percent of people with high heart disease risks such as Diabetes Mellitus Type II primarily show clinical features belonging type III Hyperlipo Proteinemia gene carriers… but why does it happen exactly? Well often family history patterns do result in those being at higher risk
Coupled with possible lifestyle factors like
- Excessive calorie intake
- Sedentary lifestyle
- Alcohol consumption
This ultimately increases upshot for typically leaner Caucasians.
That doesn’t mean other populations can’t experience mixed hyperlipidemia. Some other contributing factors include:
- Being pregnant
- Certain illnesses (e.g., thyroid disease)
- Certain medication use
- meds used to treat HIV or AIDS
- Anabolic steroids, hormones and anticonvulsants
Signs and Symptoms
Now that we’ve explored what mixed hyperlipidemia actually is, let’s talk about the kinds of symptoms you can expect if you have this condition.
Oddly enough- there aren’t any clear-cut signs! Often it remains unnoticed until more serious conditions crop up relating to heart problems from ongoing fatigue caused by disease-related plaque accumulation. Nonetheless clinical features seen in some cases:
- Xanthomas: fat deposition on parts such as Achilles tendons.
- Corneal arcus: thin white/grey ring around the cornea.
Other things doctors look at when considering whether someone has mixed hyperlipidemia is routine screening blood tests with high triglyceride/LDL levels; a key indicator, also abdominal discomfort from elevated triglycerides being stored in fat tissues may indicate insulin resistance.
It doesn’t exactly make for great cocktail party conversation–but hey ho!
Diagnosis & Treatment
You’ll need work-ups with regular lipid profile check-ins following modest calorie diets coupled with physical exercise aimed to lower cellular triacylglycerol concentration as delivered statin-fibrates combination therapy makes incremental progress towards cholesterol normalization while selectively enhancing clearance beta-VLDL disorders(LOF).
If your issues stem more from chylomicron remnants– niacin increases HDL concentrations reducing hepatocyte secretion of apolipoprotein B requiring medium-chain fatty acids but greatly lowering IMTG concentrations which regulates downstream release through bad lipoprotein particles.
So What Should You Do?
Mixing different types of lipstick colors might be fun…But mixing different types of “lipo” substances running amok in your bloodstream is not exactly cause for celebration!
Our top three tips to manage mixed hyperlipidemia:
- Make lifestyle changes- endeavor consistently healthy habits like balanced diets.
- Listen to your doctor’s advice, be rigid with regular health check-ups -especially important if there are genetic factors!
- Physical regime should provide a non-pharmacological intervention reducing the overall risk of cardiovascular disease burden while remaining patient and consistent.
While mixed hyperlipidemia isn’t necessarily fun– it’s manageable when addressed promptly with smart choices and physician oversight!
In summary–Lipids aren’t just simple fats swishing through our bloodstreams; instead they are complex molecules that have wide-ranging effects on our bodies! And those effects can either help us or hurt us –mixed-hyperlipidemaia included along with its many intricate subdivisions, sounds confusing but once broken down into its core components becomes much easier to understand!