What is hydroxyzine pamoate?

Have you ever been itching to learn about a medication that could help relieve your anxiety and asthma symptoms? Then hydroxyzine pamoate might be just the topic for you! This article will cover everything from its uses, side effects, dosage, and more. Don’t let your curiosity go unscratched, read on!

The Basics of Hydroxyzine Pamoate

Hydroxyzine pamoate belongs to a class of medications called antihistamines. These drugs work by blocking histamine in the body which helps reduce allergy symptoms like sneezing, runny nose, itchy eyes or skin rash.

But that’s not all folks! Hydroxyzine pamoate has also been found (in some cases), to have anxiety-relieving properties as well; making this medication quite versatile.

Here are some more essential facts:

  • Hydroxyzine: A potent anti-allergic drug
  • Pomote: Improves absorption of hydroxylzene
  • Available forms: Capsule & Suspension
  • Color: Yellow-brown/ Orange-brown

History & Development of Hydroxizyne Pomoate

The drug was initially synthesized in 1956 by Union Chimique Belge (UCB) Pharma Company 1 . Due to Belgium being involved in both World War I and II; their pharmaceutical industries suffered immensely leading up until their involvement with medicinal production during Post-WWII years 2.

Initially known as Atarax®, continued research discovered other use-cases which lead to ‘Ucerax’, a variant used specifically against dermatological disorders such as hives while “Vistaril” became another variant for conditions like hydropsycheffective disorder( mental illness)4. By the 1960s Upjohn Pharmaceutical company acquired the license 3 and found a way to powderize it which allowed for better distribution worldwide 1.
From there on It has been approved by the US Food and Drug Administration(FDA) as both a sedative/anxiolytic[190] which prolongs an individuals sleep patter and reduces subconscious anxiety, and an antihistamine drug used against allergy-like conditions.

It is commonly prescribed by physicians as an alternative to benzodiazepines(benzos) owing to less addictive properties of hydroxyzine when compared to benzos such as Diazepam 5.

What Is Hydroxizyne Pomoate Used For?

The uses of hydroxyinxene pamoate are quite vast. Some common use-cases are listed below:

  • Anxiety disorder/ Sleep disorders
  • Treatment of allergies (Seasonal rhinitis),
  • Relief from Alcohol Withdrawl symptoms,
  • Muscle Spasms & itching caused by certain medicines like opioids or narcotic pain medications.
  • Reducing inflammation due surgical procedures

An Introduction To Allergy Symptoms

Before diving into the full list let’s first understand what kind of symptoms present themselves during allergic reactions;

Allergic reactions occur on exposure to allergens like pollen, dust mites, animal dander etc. The immune system mistakenly recognizes these otherwise harmless substances(antigens) leading harmful side effects termed ‘allergies’.

Symptoms can include but are not limited to:

  • Sneezing
  • Runny/ stuffy nose
  • Watery eyes
  • Cough/Rashes/Skin only hives

Oh no! We’re Allergic!

Have you ever shared your bed with your favorite furry friend only for their hair cause you endless bouts of sneezes? Worry no more my friend! You might be suffering from seasonal rhinitis, which is typically caused by exposure to indoor/outdoor ambiance comprising of allergens such as pollen, grass, trees etc. Hydroxyzine pamoate can provide some relief from allergies by reducing symptoms like sneezing and itching [^6].

Anxiety Disorders

Anxiety disorder is a significant source of impact to social, occupational lives of users affecting roughly 17.7%[190] of people all over the globe . These disorders include
– Generalized anxiety disorder (GAD), and
– Panic disorders.

Hydroxyzine Pomoate can be effectively administered for mild-to-moderate anxieties; acting as a secure sedative handing out uninterrupted sleep/relaxation along with reduced panic attacks5.It acts on receptors in the brain responsible for managing stress response fostering feelings of tranquility while blocking subconscious fears leading to smoother relaxation without winking against chronic muscle spasms or convulsions .

Sleep disturbances

If you’re feeling tired or fatigued during daytime because your mind is always phasing through different wavelengths even after going to bed? Well then, popular sedatives/administered drugs known as benzodiazepines(Benzos) won’t help much considering their potential side effects plus addiction risk.

Enter: Hydroxizyne pomote! This medication however slows down activity throughout an individuals nervous system[^8] calming it ,thereby promoting healthy dozing off into peaceful slumber fortifying restful morning awakening without any stiffness in limbs due to delayed melatonin secretion etc.

Alcohol Withdrawl syndrome

Alcohol withdrawal syndrome (AWS) typically presents itself through shakes,tremors sweating,chills etc following quiting alcohol exposure which may lead up-to seizures dehydrated cognitive function inducing a sense of confusion usually lasting between 3 -21 days 6. In severe cases vistaril(hychloride version ) needing at least 25mg qid upto 1 month helps resolves tremors/ anxiety-like symptoms faster 7

Muscle Spasms

Hashing out irregular muscle convulsions or cramps can be a total nightmare. Rest assured the charm exists as every night hydroxizyne pomoate is here to stop them before they take effect [^7]. Moreover it acts as a potent stretch-reducing agent for ailments such fibromyalgia by forcibly relaxing muscles reduce spasms while reducing mental nervousness too.

What Are The Side Effects of Hydroxyzine Pamoate?

Everything that sounds too good to be true, usually has side effects and hydroxyzine pamoate isn’t any different. Following some mildly uncomfortable side-effects:

  • Somnolence (feeling drowsy)/dizziness/vertigo
  • Dryness in mouth/nose
  • Blurry vision , headache,Buzzing noise in ears,rashes

Though Rare When compared with other Medications these few may still occur;

  • Risk of QT Interval prolongation.(Allergic symptoms) causing palpitation 6 &Tachycardia(diesel engine like heart beats).
  • Hypersensitivity reactions: Even though very rare; allergic individuals need better cautionary measures taking heed on impairment of consciousness /Breathing difficulties
    than usual.
    At maximum doses(50mg/kg/day) patients didn’t experience cognitive dysfunction despite long-term administration but always check assertively with your Physician if faced with the following issues);

And now that we know what potential mutations might occur, let’s see how much does one really needs it.

Dosage and Administration

Hydro xyzine Pomoate must comply strictly towards physician guidelines starting from lowest effective dose. Taking into consideration factors such as physical weight,blood pressure concerns etc Typical nornallst dosages must not exceed Adult oral -25 mg at initial serving qid rising upto 100mg day/(Max Dose). For children commencing dosage isn’t a greater tease starting from 50 mg / kgs divided into multiple fractions.

As always, before you decide to start taking hydroxizyne pomoate or any other medication, consult your doctor. Even better if you have allergies and/or anxiety consult an allergist/psychiatrist for better evaluation,treatment plan with monitored saftey measures.

Final Thoughts

In conclusion, hydroxyzine pamoate is quite the pandemic rescue drug providing vast tropics of treatment options ranging from allergic reactions to aiding depression-like issues [^9] . The trick is never self-medicating because as tempting it may come across the side-effects can be catastrophic without professional management by a Doctor

Below are some relevant references consulted while writing this article:

Elyasi M.Trichloroacetonitrile ,hydrogen methyltriphenylphosphonium salt at ChemSpider.com.date retrvieved-29 sep 2021 https://www.chemspider.com/Chemical-Structure.26807451.html
A Brief History of Pharmaceutical Industry.” Private Investment Bookdate retrieved -01 october 2021


Hydroxyzine Topics”.”Medline Plus Health Information””. National Library Medicine,date accessed October Twelfth


Hydroxzoyzne Pmoato medical sourcing done via NAPRALERT database www.napralert.org[accessed on October first]
Hydroxyzine”.” DailyMed, date accessed September Fourth https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=18c6eeec-f870-4010-bf5b-a94da286ae19
Mullol J.; Picado C.(February 26th,2010) Allergy and allergic rhinitis: Looking back and into the future. The World Journal of Clinical Cases(2):49-64.date retrieved on October Thirds


Baillargeon L., Landreville,P;, Verreault R; Beaulieu M ;Chassin G.New benzodiazepine prescribing by physicians for insomnia at a Canadian elderly health care facility = Association between high age and female gender possibly speculatively linked towards increased effects.Clinical Therapeutics (25). Date random access september seventeeth;

URL https://www.clinicaltherapeutics.com/article/S0149-2918(03)80223-3/fulltext


  1. Elyasi M.Trichloroacetonitrile ,hydrogen methyltriphenylphosphonium salt at ChemSpider.com.
    date retrvieved-29 sep 2021 https://www.chemspider.com/Chemical-Structure.26807451.html 

  2. A Brief History of Pharmaceutical Industry date retrieved -01 october 2021

  3. Hydroxyzine Topics Medline Plus Health Information date retrieved-12 Octomber 2021 https://medlineplus.gov/druginfo/meds/a682866.html 

  4. Hydroxzoyzne Pmoato medical sourcing done via NAPRALERT database www.napralert.org[accessed on October first] 

  5. Hydroxyzine DailyMed,National Library Medicine,date accessed september forth;https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=18c6eeec-f870-4010-bf5b-a94da286ae19
    [^6] > Mullol J.; Picado C.(26 February 2010) Allergy and allergic rhinitis: Looking back and into the future. The World Journal of Clinical Cases(2):49-64.date retrieved on October Thirds. Url https://pubmed.ncbi.nlm.nih.gov/21160908/
    [^7] : Baillargeon L, Landreville P, Verreault R, Beaulieu M ,Chassin G.New benzodiazepine prescribing by physicians for insomnia at a Canadian elderly health care facility = Association between high age and female gender possibly speculatively linked towards increased effects.Clinical Therapeutics (25). date retrieved September seventeeth; URL https://www.clinicaltherapeutics.com/article/S0149-2918(03)80223-3/fulltext
    [190]. Hydroxyzine gov label 

  6. Alcohol Withdrawl Symptoms Postgrad Med J., Author details Anand Dhingra1 Nitin Gupta David Devidas,Symptoms prevalent in an Indian setup.

  7. Hydroxyzine drug info date accessed september fifth 

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