What is anti aromatase?

If you’re wondering what anti-aromatase is, don’t worry, you’re not alone. In this article, we’ll be diving deep into this topic to bring you all the information you need to know (and maybe even some stuff you didn’t).

The Basics

To start off with, let’s define what aromatase actually is. Basically, it’s an enzyme that converts testosterone into estrogen in the body.

Now for those of us blessed with a Y chromosome, we generally produce more testosterone than estrogen – which isn’t always ideal. This excess testosterone can lead to side effects such as gynecomastia (i.e., man-boobs). So how do we combat this problem?

Enter anti-aromatase.

Anti-what-now? Simply put, it’s a class of drugs that prevents the conversion of testosterone into estrogen by inhibiting the aromatase enzyme.

Let’s take a closer look at how they work:

Mechanism of Action

Anti-aromatases prevent androgenic steroids from being converted into estrogens and thus increase serum LH/FSH levels through negative feedback inhibition on hypothalamus/pituitary gland function (if that went over your head, just know that they inhibit the production of estrogens).

One well-known example of an anti-aromatase drug is Arimidex (Anastrozole). This medication works by binding to the active site on the aromatase enzyme itself and preventing any interaction between it and its substrate – effectively neutralizing its ability to convert testosterone into estrogen.

So far so good? Great! Now let’s talk about when one might use these inhibitors:

Why use Anti-Aromatases?

As mentioned earlier, people may choose/use anti-aromatases for many reasons; typically:

1. To reduce side effects associated with taking performance-enhancing drugs
2. To treat estrogen-dependent cancers
3. To manage endocrine disorders (like what? Keep reading for more!)

Medical Uses

Like many medications, anti-aromatase drugs are largely unknown to the general public – after all, how often do we talk about our love of inhibitors at dinner parties?

However, these drugs have been used in medical settings since the 1990s.

#1 Treating Breast Cancer

At this stage in development (2021), breast cancer remains one of the most common types of cancer.

Fun fact: Around 70% or more (5 out of every 7) cases are found to be Estrogen Receptor-positive (ER+).

This means that Estrogen fuels tumor growth. As a result, treatment frequently involves inhibiting aromatase activity as part of a multi-pronged approach (‘multi-what’? Just think several treatments).

#2 Reducing excess Endometrial thickness

Endometriosis is caused by excessive exposure to estrogens and hormonal imbalances which can lead to thickening within the uterus lining causing pain and discomfort during menses.
Anti-Aromatases inhibit production therefore reducing over exposure and ultimately further damage

Performance Enhancement Therapy

The use of anabolic steroids continues despite being banned by US sports organizations (& globally) due to their performance-enhancing properties. They are infamous for causing side effects like acne, shrunken testicles(yikes!), gynecomastia(“Not my guy!”) And high blood pressure(“take me off it!”) amongst others including mood swings & Stroke so inhibitors come into play…

Anti-Aromatase & Polypharmacy Regimens

Inhibitors cannot be administered alone which results in Polypharmaceutical therapy; either with Selective Androgen Receptor Modulators (SARMs eg Nolvadex/Tamoxifen), or with Human Chorionic Gonadotropin (HCG eg. Clomiphene and Letrozole). In some cases, progestins like Cabergoline are added to regulate prolactin secretion which stems from using certain steroids.

What Does This Mean?

In essence, combining these medications takes multiple angles of attack against problematic estrogen production- reducing possible side effects associated with excessive synthetic hormone levels in the bloodstream.

Expert advice: make sure you consult your Doctor before adding any therapy regimen as each medication has individual reactions and could be harmful when taken wrongly.

Side Effects

No drug is 100% positive without adverse means; Anti-aromatase inhibitors can cause some side effects that include:

• Headaches
• Hot flashes
• Skin rash
• Joint pain(~~you are getting old man!~~)
  -The possibility of Osteoporosis(what???)

The thing about these side effects is they result primarily due to low estrogen levels in the body –especially at higher doses – than inhibiting aromatase itself so people taking such inhibitors usually supplement additional medication that may reduce such risks (no shortcuts fam!).

As always, speaking extensively with a medical professional who can advise on dosages and watched for any negative reactions is most recommended.

Wrap Up

So there you have it – everything you wanted to know (and maybe didn’t want to know) about anti-aromatase drugs!

Whether its preventing feminizing features resulting during steroid cycles or better control & quality treatment regimes for cancer patients undergoing chemotherapy; Understanding how by working well with other compounds, an injury-free lifestyle can oftentimes depend on using one tool correctly…ie Anti-Aromatases Gym-rats what’s poppin now?!

Until next time!