Table of Contents
What is Plaquenil?
Plaquenil, also known as Hydroxychloroquine, is a commonly prescribed medication for the treatment of autoimmune diseases, such as lupus, rheumatoid arthritis, and Sjogren’s syndrome. It is also used for the prevention and treatment of malaria.
How Does Plaquenil Work?
Plaquenil works by interfering with the communication between cells in the immune system. It modifies the activity of immune cells, which are responsible for attacking healthy cells in autoimmune diseases. The drug also prevents the growth and replication of the parasites that cause malaria.
What Drugs Interact with Plaquenil?
Plaquenil can interact with various drugs and cause harm to the body. Some common drugs with which Plaquenil interacts are mentioned below:
Antacids
Antacids, which are used to treat heartburn and stomach ulcers, can reduce the absorption of Plaquenil. Hence, it is necessary to maintain a gap of at least 4 hours between the administration of an antacid and Plaquenil.
Diabetes Medications
Plaquenil can increase the blood sugar level in diabetic patients. Hence, it is necessary to monitor blood sugar levels regularly if Plaquenil is taken along with diabetes medications.
Methotrexate
Methotrexate is a chemotherapy drug that is also used to treat autoimmune diseases. Taking both Methotrexate and Plaquenil together can increase the risk of liver damage or affect the bone marrow negatively. Hence, it is necessary to monitor the liver and blood tests regularly if these drugs are taken together.
Penicillamine
Penicillamine is used to treat Wilson’s disease and rheumatoid arthritis. Taking Penicillamine along with Plaquenil can increase the risk of vision loss or retinal damage. Hence, it is necessary to monitor the vision regularly if both drugs are taken together.
Digoxin
Digoxin is used to treat heart conditions. Taking Plaquenil along with Digoxin can increase the risk of Digoxin toxicity. Hence, it is necessary to monitor the Digoxin levels in the blood regularly if both drugs are taken together.
Cyclosporine
Cyclosporine is used to prevent the rejection of transplanted organs or to treat autoimmune diseases. Combining Cyclosporine with Plaquenil can increase the risk of kidney damage. Hence, it is necessary to monitor the kidney function regularly if both these drugs are taken together.
What Are the Side Effects of Plaquenil Interactions?
Plaquenil interactions can cause several side effects, including:
- Diarrhea
- Nausea and vomiting
- Dizziness
- Headache
- Abdominal pain
- Decreased appetite
- Shortness of breath
- Irregular heartbeat
- Vision problems
- Hearing loss
- Hair loss
If you experience any of these symptoms, it is necessary to inform your doctor immediately.
What Precautions Should You Take While Taking Plaquenil?
You should take the following precautions while taking Plaquenil:
- Inform your doctor about all the medications you are taking.
- Do not take Plaquenil if you are allergic to it.
- Inform your doctor if you have any heart, liver, kidney, or vision problems before taking Plaquenil.
- Maintain a healthy diet and exercise routine while taking Plaquenil.
- Avoid exposure to sunlight or ultraviolet rays while taking Plaquenil, as it can increase the risk of skin rash or sunburn.
What Is the Recommended Dosage of Plaquenil?
The recommended dosage of Plaquenil depends on the condition being treated. The usual dosage for adults is 400mg to 600mg daily, taken with food. For malaria prevention, the dosage is 400mg once a week, starting two weeks before travelling to a malaria-endemic area, and continuing for 4 to 8 weeks after leaving the area.
Conclusion
Plaquenil is a commonly prescribed medication for the treatment of autoimmune diseases and the prevention of malaria. However, it should be taken with caution, as it can interact with various drugs and cause harm to the body. If you experience any side effects or have any concerns about the medication, it is advisable to contact your doctor immediately.
Frequently Asked Questions
Can Plaquenil interact with Antacids?
Yes, Antacids can reduce the absorption of Plaquenil. Hence, it is necessary to maintain a gap of at least 4 hours between the administration of an antacid and Plaquenil.
What precautions should I take while taking Plaquenil?
Inform your doctor about all the medications you are taking. Do not take Plaquenil if you are allergic to it. Inform your doctor if you have any heart, liver, kidney, or vision problems before taking Plaquenil. Maintain a healthy diet and exercise routine while taking Plaquenil. Avoid exposure to sunlight or ultraviolet rays while taking Plaquenil, as it can increase the risk of skin rash or sunburn.
What is the recommended dosage of Plaquenil?
The recommended dosage of Plaquenil depends on the medical condition being treated. The usual dosage for adults is 400mg to 600mg daily, taken with food. For malaria prevention, the dosage is 400mg once a week, starting two weeks before travelling to a malaria-endemic area and continuing for 4 to 8 weeks after leaving the area.
References:
- https://www.medicalnewstoday.com/articles/plaquenil#drug-interactions
- https://www.rxlist.com/plaquenil-drug.htm#interactions
- https://www.mayoclinic.org/drugs-supplements/hydroxychloroquine-oral-route/before-using/drg-20064216