What drugs does grapefruit interact with?

Grapefruit is one of the most popular fruits in the world. It’s not just delicious, but also contains a lot of vitamin C and other essential nutrients that are good for your health. However, did you know that grapefruit can also interact with certain drugs? This might come as a surprise to some people, but it’s important to know which drugs are affected so you can avoid any adverse reactions. In this article, we’ll discuss the drugs grapefruit interacts with.


While grapefruits are an excellent source of vitamin C and other nutrients, they may potentially cause harmful effects when eaten alongside specific medications. The chemicals in grapefruits alter how certain enzymes in your intestines break down medications, leading to changes in absorption levels by up to 60% from typical doses.

How does Grapefruit work?

Before delving into which medications do or do not have interactions with it’ll be best first to understand how grapefruits function regarding drug interaction. Grapefruits contain furocoumarins compounds that block cytochrome P450-3A4 (CYP3A4), found predominantly liver enzyme systems responsible for processing many common pharmaceuticals used today.

What compounds and information contained within furocoumarin cause dosage concerns depends on each patient’s unique system makeup if there is an active medication regiment where pharmacists would be educated about potential issues relating back specifically associated interactions typically seen within prescriptions administered same time sipping freshly pressed juice.

Which Drugs React With GrapeFruit?

It’s essential to check with your doctor before starting new medicine or ingesting large amounts of citrus fruits like oranges or grapefuit because some food-drug combinations could turn deadly quickly at first glance.
Yet here are few universal examples:

Calcium Channel Blockers

One class associated types calcium slow blood pressure via blocking calcium channels vessels’ muscle walls. When grapefruit interacts with calcium channel blockers, they block the enzyme CYP3A4 found in your liver and digestive system. This blocks calcium channels as a result, leading to blood pressure decrease reaction of about 50 percent that lasts for several hours.

Some major examples include Nifedipine (Procardia), Amlodipine (Norvasc) felodipine isradipine etc.


Immunosuppressive drugs are used to prevent transplant rejection following organ transplantation while also being indicated off-label reducing autoimmune diseases symptoms like rheumatoid arthritis or lupus erythematosus. Grapefruits can interact adversely these medicines increase bioavailability the calcineruin inhibitors by up to two times more than normal levels when taken together – putting patients at risk kidney failures.

Transplant medication cyclosporin group – taking such poses food-drug interaction risks erythromycin Ketoconazole tacrolimus some HIV protease inhibitors.


Patients diagnosed high cholesterol routinely rely on treatment statin medications such as atorvastatin Pitavastatin rosuvastatin simvastatin lovaststain pravaStain those reduce LDL-cholesterol one’s body space is have decreased cardiovascular disease progression likelihood over time regardless grapefruit still presents potential problem alongside this therapy for many people because its effects can be unpredictable depending dosages ate sensitivity ranges exercised simultaneously drug regimens consumed certain active ingredients commonly found within most supplements shared oral human consumption.

Statins delivered gemfibrozil Protease Inhibitors Amprenavir amprenavir Indinvair tipranvir Saquinovirclarithromycin antifungal itraconazole ketoconazole fluoroquine azole Diltiazem Verapamil Erythomycin might encounter their livers compromised potentially ledio lethal consequences overly build of toxicity within the tissues.


Grapefruit juice can delay hepatic metabolism of fexofenadine by up to 339%. Therefore, drinking grapefruit juice with Allegra may cause high levels of this antihistamine in bloodstreams potentially leading to adverse side effects.

Other Medications That GrapeFruit Can Affect

  • Anxiety medicines such as Xanax and Valium
  • Blood thinners including Warfarin( Coumadin) with concurrent grapefruit use could trigger hemorrhagic incidents because its vitamin K lowering capability
  • Erectile dysfunction pills, including Viagra (sildenafil) or Cialis(tadalafil)
  • Anti-inflammatory steroids like predinisone
  • Anti-seizure medication carbamazepine

It’s important also mandatorily ask a pharmacist when it is safe to juice consumption even if symptom relief benefits might seem deliciously worth trying without caveats other minor interactions perhaps less common ones.

What are the Symptoms?

When you start eating grapefruits or any citrus fruit, keep an eye on your symptoms. If you experience an unusual reaction after taking medicine coupled with recently ingesting grapefruit, contact health care professional right away for guidance since some symptoms include:

  • Decreased concentration
  • Fainting/ dizziness
  • Rapid heartbeat issues/ palpitations
  • Muscle pain and weakness; stomach upset If prolonged report immediately

Let’s face it, nobody deserves these things happening to them than simply enjoying their love for fruits!


In conclusion so vital that those currently prescribed medications should refresh knowledge one’s pharmacists about what food-drug interactions occurring over time exercise caution accordingly before enjoying becoming adventurous enjoyments various culinary masterpieces out there replete often produce remarkable symbiotic dishes! Because better be safe than sorry forever!

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