What disease is thalidomide now used to treat?
Thalidomide is an oral medication used for treating the skin conditions of leprosy, a disease caused by a parasite, Mycobacterium leprae. The mechanism of action of thalidomide is not well understood. The immune system reaction to Mycobacterium leprae plays an important role in producaing the skin manifestations of leprosy.
Does thalidomide have an analgesic effect? The analgesic effect of thalidomide is not due to a central effect, since the drug had no effect in the hot plate test.
What is thalidomide prescribed for? Thalidomide is a sedative that used to be prescribed to treat anxiety, tension, gastritis and insomnia.
What was thalidomide used for? This medication is used to treat or prevent certain skin conditions related to Hansen’s disease, once known as leprosy (erythema nodosum leprosum). Thalidomide is also used to treat a certain type of cancer (multiple myeloma). It works in Hansen’s disease by reducing swelling and redness (inflammation).
What are the effects of thalidomide on embryonic development?
What are the effects of thalidomide on embryonic development? By this intercalation, thalidomide represses the promoter regions of insulin growth factor-1 (IGF-1) and fibroblast growth factor-2 (FGF2), both responsible for stimulating angiogenesis. Intercalation is also accepted as a plausible hypothesis for why embryonic limb buds cease to form.
How does thalidomide inhibit the growth of angiogenesis? At the molecular level, thalidomide inhibits angiogenesis by intercalating or inserting itself into guanine-cytosine (G-C) rich regions of DNA. By this intercalation, thalidomide represses the promoter regions of insulin growth factor-1 (IGF-1) and fibroblast growth factor-2 (FGF2), both responsible for stimulating angiogenesis.
How are the two forms of thalidomide different? This is where the concept of enantiomers comes in. The thalidomide molecule occurs naturally in two forms, (R)- thalidomide and (S)- thalidomide, which are enantiomers, or mirror image molecules, of each other. The (R)-form has remedial properties, while the (S)-form is a teratogen, an agent that can cause birth defects.
Are there any problems with the FDA after thalidomide? Following the thalidomide event, regulations were made stricter than this. Nevertheless, the FDA still continues to be peppered with issues. One of the most serious problems regarding the FDA, particularly in recent years, has been its tendency to release serious warnings about drugs after they have been placed on the market.