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What are bisphosphonates and how do they work?

work by slowing down the cells which break down bone (Osteoclast

An osteoclast is a type of bone cell that breaks down bone tissue. This function is critical in the maintenance, repair, and remodelling of bones of the vertebral skeleton. The osteoclast disassembles and digests the composite of hydrated protein and mineral at a molecular level by secreting acid and a collagenase, a process known as bone resorption. This process also helps regulate the level of blood calcium.

). Therefore they slow down bone loss, allowing the bone building cells (Osteoblast

Osteoblasts are cells with a single nucleus that synthesize bone. However, in the process of bone formation, osteoblasts function in groups of connected cells. Individual cells cannot make bone. A group of organized osteoblasts together with the bone made by a unit of cells is usually called the osteon.

) to work more effectively. They can help to strengthen bone and help to prevent it getting any weaker. People who take a bisphosphonate are less likely to break (fracture) a bone.

What are Bisphosphonates and how do they work? Bisphosphonates work by slowing down the cells which break down bone (osteoclasts). Therefore they slow down bone loss, allowing the bone building cells (osteoblasts) to work more effectively. They can help to strengthen bone and help to prevent it getting any weaker.

When to stop bisphosphonates? Because the medication lasts in the bones for some time after you stop taking it, your doctor might recommend stopping bisphosphonates after three to five years — especially if your overall risk of fracture is low.

When to stop bisphosphonate? You may be able to discontinue therapy with bisphosphonates after 5 years of use if your fracture risk is low. Continue to follow up with your doctor for monitoring and repeat bone density scans about every 1-2 years; your doctor will decide how often the test should be repeated.

What are bisphosphonates used for? Bisphosphonates are a group of drugs used to help prevent and treat bone loss. They’re prescribed for people with osteopenia (softening of the bones), osteoporosis (brittle and easily broken bones), Paget’s disease, and certain bone cancers.

When to stop bisphosphonates?

When to stop bisphosphonates? Because the medication lasts in the bones for some time after you stop taking it, your doctor might recommend stopping bisphosphonates after three to five years — especially if your overall risk of fracture is low.

When to stop bisphosphonate? You may be able to discontinue therapy with bisphosphonates after 5 years of use if your fracture risk is low. Continue to follow up with your doctor for monitoring and repeat bone density scans about every 1-2 years; your doctor will decide how often the test should be repeated.

What are bisphosphonates used for? Bisphosphonates are a group of drugs used to help prevent and treat bone loss. They’re prescribed for people with osteopenia (softening of the bones), osteoporosis (brittle and easily broken bones), Paget’s disease, and certain bone cancers.

How do bisphosphonates treat osteoporosis? Bisphosphonates are able to help in osteoporosis by killing off osteoclasts. This is done by the substance being laid down in the bone, then being absorbed into the osteoclast when it consumes bone and then destroying the osteoclast.