Laboratory diagnosis of leprosy pdf?

Leprosy is not a laughing matter, but that doesn’t mean we can’t lighten the mood when discussing laboratory diagnosis of leprosy in PDF format. Yes, you read it right- PDF! Before diving into the nitty-gritty details, let’s get to know more about this skin disease.

First things first – What is Leprosy?

Leprosy or Hansen’s Disease is an infectious disease caused by Mycobacterium leprae. It mainly affects the nerves and results in progressive damage to the skin and other organs. This chronic disease may take years to manifest symptoms and can lead to deformities if left untreated.

But how does one contract Leprosy?

Contrary to popular belief, Leprosy is not highly contagious. It spreads through prolonged contact with nasal droplets from infected persons or armadillos as they are natural hosts for M.leprae.

Is there hope for people who have contracted Leprosy?

Yes! Once diagnosed correctly through laboratory tests, patients can be treated with multidrug therapy (MDT), which has been known to cure most cases within 6-24 months.

Thankfully modern medicine has blessed us with several types of laboratory diagnosis methods which make detecting this condition relatively easy.


Don’t worry your precious eyesight will stay intact because microscopy includes staining body fluids or tissue specimens containing microorganisms then observing them under a microscope at high magnification.No glasses required!


  • Cheap
  • Fast Process


  • Less Sensitive than Other Tests

PCR (Polymerase Chain Reaction)

PCR amplifies genetic material specific for Mycobacterium Leprae; hence it’s very sensitive since it only detects genetic material from this bacterium.


  • Highly Sensitive
  • Less Dependent on Experienced Staff


  • Expensive


Serology tests detect antibodies produced by the infected host to M.Leprae. However, they have poor sensitivity and specificity of leprosy diagnosis unless paired with other diagnostic methods.


  • Cost-Effective

Histopathological examination (Biopsy)

The biopsy involves taking a sample tissue for a microscopic assessment after staining it. The presence of granulomas containing Mycobacterium Leprae in clinical specimens indicates an infection with Leprosy. Yikes!


  • Provides Most Specific Diagnosis


  • Invasive Procedure

In conclusion, laboratory diagnosis for leprosy is very important because it helps clinicians confirm patients’ symptoms correctly hence allowing them to provide the best course of treatment available.In today’s world where viruses are snapping at our heels constantly, technology has proven that modern medicine can fight against various diseases including Hansen’s disease or Leprosy just at everyone’s fingertips(including PDFs).Luckily we were able lightened up these tedious discussions about laboratory diagnosis while emphasizing how vital early disease monitoring is.Because who says learning about essential medical issues cannot bring some laughter?