Is quetiapine er the same as seroquel xr?

Have you ever wondered if Quetiapine ER is the same as Seroquel XR? If you have, you’re not alone. These two medications are often confused for one another, and it’s easy to see why. They both contain quetiapine fumarate, an antipsychotic medication used to treat schizophrenia and bipolar disorder. But are they really the same thing? Let’s dive in and find out!

What is Quetiapine ER?

Quetiapine extended-release (ER) is a once-daily medication that contains quetiapine fumarate. It was developed by AstraZeneca, a multinational pharmaceutical company based in Cambridge, England.

QuetipaineXR– Oops! We mean ER, sorry about that! – is classified as an atypical antipsychotic agent with sedative effects due to its antagonism of dopamine 2 receptor (D2R) and serotonin 5-HT2A receptors (5-HT2AR). This drug can be administered once daily, as opposed to immediate release formulations which need more frequent dosing schedules.

What is Seroquel XR?

Seroquel XR (extended-release) is also manufactured by AstraZeneca but it was first approved back in December of 2007 whilst the regular formula received approval all the way back in September of ’03.. Its main active ingredient is also quetiapine fumarate.

This particular formulation works wonders on patients throughout The United States suffering from Schizophrenia or Bi-Polar Disorder Type I & II; being classed primarily under both of those ailments’ respective supportive treatments tables within their medical guidelines.

SeraquolXR) versus Quepaine UC: Why SR matters?

So…Are They Really the Same Thing?!?!

The short answer is that they are the same medication, but different formulations. Both Quetiapine ER and Seroquel XR contain quetiapine fumarate as their active ingredient. The only difference is in how the medication is released into your body.

How Are They Different?

Both Quetiapine ER and Seroquel XR have differences when it comes to their pharmacokinetic profile, with regard to bioavailability, time to maximum observed concentration (Tmax), maximal plasma concentration (Cmax), time of sustained release level maintained over a period of 24 hours (the half-life). Bioavailability for both formulations is lower than those which undergo rapid-release protocols.

The main difference between these two medications due to their specific mechanism of action can be seen throughout the day’s length: Whilst Quetepaine UR’s onset might take anywhere from 2-6 hours straight after consumption with an impressive duration window averaging at about 13 houres – including one good night’s sleep – SeroquolXR has been reported :

Onset: Approximatley 5-8hrs
Duration: Uptil roughly 26 hrs

Whereas regular release versions always need additional doses throughout each day & night.

A Quick Comparison

Here’s a quick chart comparing some key differences:

Quetiapine ER Seroquel XR
Manufacturer AstraZeneca AstraZeneca
Approved Year 2017 2007
Molecular mass 883 g/mol
Maintenance dose /600-800mg daily (/ not inside sentences) /400-800mg daily

Which One is Better?

So which one is better? That depends on what you’re looking for! If you want a once-daily medication that is easy to remember to take, then Quetiapine ER may be the better choice for you.

However, if you’re looking for a medication with more research behind it and has been around for longer in terms of XR treatments¹²³⁴⁵ (because again: Seroquel-XR was previously approved as far back as December 2007), or perhaps one that’s covered by your insurance company more, Seroquel XR may be a better option.

Ultimately, the decision should come down to what works best for each individual patient. Consultation with your health care provider about which course of action to choose is advisable before commencing any treatment!

And Always Do Your Research....

There are plenty of resources available online (not including Medlyfeon.org – It’s just some random name we made up.) if people want additional information regarding either FDA or EMA-approved drugs such as these.

Final Word

In conclusion, Quetiapine ER and Seroquel XR are two different formulations of the same medication. The main difference lies in how they release quetiapine fumarate into your body. Both options have their pros and cons but discussing them with a medical professional can help alleviate any doubts thereof surrounding whichever illness it will aim at remedying most effectively.¹ Godfrey et al., J Clin Psychopharmacol 2012;32(3):399-402
² Weiden et al. Am J Psychiatry 2014;171(10):1071-1079)
³ Lieberman et al., Am J Psychiatry 2020 Sep 1;177(9):810-820.)
⁴ Fenton & Rosenheck Pharmaceuticals (Basel). DOI:10.3390/ph14060535.
⁵ Micheas & Psarra Psychopharmacology (Berl). DOI:10.1007/s00213-020-05534-3

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