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Is colchicine nephrotoxic?

As nonsteroidal anti-inflammatory drugs (NSAIDs) are potentially nephrotoxic, colchicine is used frequently for both treatment and prevention of acute gout attack. Although colchicine is a relatively safe medication, it has been reported to be toxic.Cited by: Publish Year: 

How does colchicine work in treating gout? Colchicine is an alternative treatment for gout attacks for those people who cannot take anti-inflammatory painkillers. It works by reducing the number of white blood cells which travel into the inflamed areas. This helps break the cycle of inflammation and reduces the swelling and pain of the gout attack.

Is colchicine safe for kidneys? Since Colchicine is excreted 10- 20 % unchanged in the kidneys it is highly probable to cause toxic accumulation in a renal failure patient. Colchicine can not be removed through dialysis nor does it have an antidote to combat any toxic effect.

Is colchicine an antibiotic? Colchicine is used to prevent or treat attacks of gout (also called gouty arthritis). This condition is caused by too much uric acid in the blood. An attack of gout occurs when uric acid causes inflammation (pain, redness, swelling, and heat) in a joint. Colchicine does not cure gout, but it will help prevent gout attacks.

What is colchicine toxicity? Colchicine toxicity: The toxic reaction of the body to the substance, possibly via allergic reaction or overdose. More detailed information about the symptoms, causes, and treatments of Colchicine toxicity is available below.

What you should know before taking colchicine for gout?

What you should know before taking colchicine for gout? For patients taking large amounts of colchicine only when needed to relieve an attack: Start taking this medicine at the first sign of the attack for best results. Stop taking this medicine as soon as the pain is relieved or at the first sign of nausea, vomiting, stomach pain, or diarrhea.

Is colchicine the right medicine for gout? Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults. Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur.

How can colchicine kill you? Deaths – both accidental and intentional – have resulted from overdose of colchicine. Typical side effects of moderate doses may include gastrointestinal upset, diarrhea, and neutropenia. High doses can also damage bone marrow, lead to anemia, and cause hair loss.

When to stop taking colchicine? Stop taking this medicine as soon as the pain is relieved or at the first sign of nausea, vomiting, stomach pain, or diarrhea. Also, stop taking colchicine when you have taken the largest amount that your doctor ordered for each attack, even if the pain is not relieved or none of these side effects occurs.