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How much diphenhydramine is fatal to humans?

The lethal dose of Diphenhydramine Citrate

Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold.

has been estimated to be 20 to 40 mg/kg for adults. For children, the lethal dose is 500 milligrams (mg). According to a 2013 report from the American Association of Poison Control Centers (AAPCC), most intoxication and overdose cases occur in children six years old and under.

Can diphenhydramine kill you? The answer is yes, although you would likely have to ingest large doses of both. If you overdose on alcohol and diphenhydramine and lose consciousness, death is one of the risks. Despite the fact that it’s commonly used and easily available over the counter, Benadryl is a potent drug.

How much diphenhydramine do you have to take to overdose? More than 500 mg, which is more than 40 times the recommended dose, may lead to a state of delirium, hallucinations, and other overdose symptoms. Anecdotal evidence about diphenhydramine highs indicates that the effects are more often uncomfortable and unsettling instead of enjoyable.

How much diphenhydramine HCI can I safely take? Diphenhydramine Hydrochloride: 25 to 50 mg orally every 4 to 6 hours as needed. -Maximum dose: 300 mg/day. Parenteral: 10 to 50 mg deep IM or IV as needed, and may increase to 100 mg if required. -Maximum dose: 400 mg/day.

Can taking too much diphenhydramine? As with any medication, it is possible to take too much diphenhydramine. The specific effects of an overdose with diphenhydramine can vary, depending on a number of factors, including the diphenhydramine dosage and whether it was taken with any other medications or substances.