How long after benadryl can i drink?

You may be wondering how long it takes for the sedating effect of Benadryl to wear off before you can enjoy an alcoholic beverage, or five. And if your answer is: ‘I was already drinking when I took my allergy medication’, well then, good luck to you! Thankfully, we’re here with all the answers on this particular quandary.

The Basics

Benadryl (diphenhydramine) is an antihistamine commonly used to treat allergies and cold symptoms. It’s classified as a first-generation histamine blocker meaning it has effectiveness in treating allergies but has a known sedative effect which makes people drowsy. Now let’s talk about what happens if you mix Benadryl and alcohol.

Mixing Alcohol and Benadryl

Mixing alcohol and drugs are generally not recommended – unless one doesn’t care much for life expectancy- particularly since both could have similarly undesirable side effects such as sleepiness, impaired motor coordination, memory loss or slow reflexes.

Don’t get us wrong though – there isn’t something inherently evil about mixed drinks (depending on how much they’re forewarned) but doing so while taking an antihistamine like Benadryl elevates its potential risks.

What Happens If You Mix Them Anyway?

Drinking alcohol after taking diphenhydramine might result in increased risk factors such as:

  • Dizziness
  • Nausea
  • Vomiting
  • Rapid heartbeat
  • Difficulty breathing or shallow breathing
  • Blurred vision

In some people who mix these substances together would develop acute asthma attacks that require emergency medical treatment right away.

So technically speaking – Do not drink after ingesting diphenhydramine until at least six hours later.

When Can You Drink Safely?

Determining the safe wait period can be a bit challenging since it hinges on several factors:

  • Your age
  • Weight
  • Metabolism speed

However, there is an underlying consensus which states that you should allow for at least six hours after ingesting diphenhydramine before consuming alcohol.

Additional points to consider when factoring in your metabolisim rate:
-Females typically process alcohol slower than men while individuals with a higher bodyweight tend to break down and eliminate alcohol faster.

Factors That Affect How Alcohol and Benadryl interact

Here are three crucial factors one must keep in mind when trying to assess how Benadryl/diphenhydramine impacts alcohol eliminating timespan from our system;

1. Dosage of Diphenhydramine Ingested.

Doses under 50 mg per tablet shouldn’t have cocktail-shifting effects but not considering everyone reacts differently to medication, so use this purely as a rule-of-thumb rather than gospel accuracy.

2. Frequency of Use of Diphenhydramine.

Recurring use diminishes our tolerance and lessens its effectiveness over time; because drink size magnifies with repeated dosages – this means we’d need longer intervals between taking pill-based meds & enjoying beverages (So resist that impulse to pop another allergy med before last night’s world record).

3. Individual metabolic rates

Ever noticed how some folks handle their drink better or worse than others? Here’s why – “metabolic rate”. As referenced earlier weight adds major influence here, meaning individuals who weigh more will often digest Alcohol quicker off their systems compared with someone who weighs less.


In conclusion, drinking responsibly requires us all to interpret each situation uniquely without overlooking critical warning signals produced by mixing already known incompatible substances like Benadryl & Alcohol . Ideally its best advised waiting for about six hours after taking diphenhydramine before drinking anything alcoholic at all – this could again be shorter or longer depending on individual metabolic rate differences. Stay safe, keep laughing & remain allergic to bad life choices.


In summary:

1) Alcohol and drugs are generally not compatible if you care about your limbs.
2) Mixing Benadryl/diphenhydramine with booze puts more strain on the body than either one independently.
3) Wait for roughly six hours before having cocktails post-diphenhydramine ingestion;

a) This time span may vary from person-to-person due to factors like; Individual Weight, Usage Frequency & Diphenhydramine Dosages taken
Until next time, stay curious but responsibility ‘Allergen-free’.

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