How do bisphosphonates work?

How do bisphosphonates work? Bisphosphonate

Bisphosphonates are a class of drugs that prevent the loss of bone density, used to treat osteoporosis and similar diseases. They are the most commonly prescribed drugs used to treat osteoporosis. They are called bisphosphonates because they have two phosphonate (PO(OH)₂) groups. They are thus also called diphosphonates.

work by slowing down the cells which break down bone (Osteoclast

). Therefore they slow down bone loss, allowing the bone building cells (Osteoblast

Osteoblasts are cells with a single nucleus that synthesize bone. However, in the process of bone formation, osteoblasts function in groups of connected cells. Individual cells cannot make bone. A group of organized osteoblasts together with the bone made by a unit of cells is usually called the osteon.

) to work more effectively. They can help to strengthen bone and help to prevent it getting any weaker.

When to stop bisphosphonates? Because the medication lasts in the bones for some time after you stop taking it, your doctor might recommend stopping bisphosphonates after three to five years — especially if your overall risk of fracture is low.

When to stop bisphosphonate? You may be able to discontinue therapy with bisphosphonates after 5 years of use if your fracture risk is low. Continue to follow up with your doctor for monitoring and repeat bone density scans about every 1-2 years; your doctor will decide how often the test should be repeated.

What are bisphosphonates used for? Bisphosphonates are a group of drugs used to help prevent and treat bone loss. They’re prescribed for people with osteopenia (softening of the bones), osteoporosis (brittle and easily broken bones), Paget’s disease, and certain bone cancers.

How do bisphosphonates treat osteoporosis? Bisphosphonates are able to help in osteoporosis by killing off osteoclasts. This is done by the substance being laid down in the bone, then being absorbed into the osteoclast when it consumes bone and then destroying the osteoclast.

When to stop taking Fosamax?

When to stop taking Fosamax? Stop using Fosamax and call your doctor at once if you have: chest pain, new or worsening heartburn; difficulty or pain when swallowing; pain or burning under the ribs or in the back; severe heartburn, burning pain in your upper stomach, or coughing up blood;

Should I keep taking Fosamax for my osteoporosis? Fosamax is used in women to treat or prevent osteoporosis caused by menopause and in men and women to treat osteoporosis caused by taking steroids. Fosamax is also used to increase bone mass in men who have osteoporosis, and to treat Paget’s disease of bone in men and women. Warnings. You should not take Fosamax if you have problems with your esophagus, or low levels of calcium in your blood. Do not take Fosamax if you cannot sit upright or stand for at least 30 minutes after taking the

How long should you take certain osteoporosis drugs? Bisphosphonates, the most common type of osteoporosis medications, are typically taken for three to five years. After that, your doctor will consider your risk factors in determining whether you should continue to take these or other osteoporosis medications.

Are bisphosphonates safe? Bisphosphonates have been shown to be safe and effective for up to 10 years of treatment, depending on the medication. However, even if you stop taking the medication, its positive effects can persist. That’s because after taking a bisphosphonate for a period of time, the medicine remains in your bone.