How are bisphosphonates administered?

The three ways in which they can be taken (administered) are:

  • by mouth (orally)
  • through a drip into a vein (intravenous infusion)
  • by an injection into a vein (intravenous injection).

How often should you take a bisphosphonate injection? Injections are usually given by a specialist nurse. Bisphosphonates are taken either once a day, once a week (on the same day of the week), or once a month (on the same day of the month), depending on the one prescribed. Most people take their bisphosphonate first thing in the morning before they eat or drink anything.

Where does bisphosphonate go after it leaves the body? Of the bisphosphonate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly adsorbed onto the bone surface.

Which is worse oral or IV bisphosphonate therapy? According to the information currently available, risk for developing bisphosphonate associated osteonecrosis of jaw is higher in patients on IV bisphosphonate therapy than the patients on oral bisphosphonates as orally they are poorly absorbed.

What is the role of bisphosphonates in clinical practice? ROLE IN CLINICAL PRACTICE. As aforementioned, bisphosphonates promote the apoptosis of osteoclasts actively engaged in the degradation of mineral on the bone surface. Accordingly, bisphosphonates have become the primary therapy for managing skeletal conditions characterized by increased osteoclast-mediated bone resorption.