Does mono cause lack of appetite?

Understanding Mononucleosis

Mononucleosis, also referred to as mono, is a viral infection that affects the lymphatic system. It is caused by the Epstein-Barr virus (EBV) and is commonly experienced by adolescents and young adults. Its symptoms vary, but some of the most common include sore throat, fever, headaches, and fatigue. Apart from these, patients with mono may also experience a loss of appetite.

What Is Loss of Appetite?

Loss of appetite, also known as anorexia, is a condition where a person experiences a lack of hunger, leading to reduced food intake. It can be mild or severe and may be caused by several factors such as illness, stress, and medication.

Mono and Loss of Appetite

Studies have shown that loss of appetite is a common symptom among individuals with mono. Research findings suggest that the virus causes a disruption in the body’s immune system, which leads to a lack of hunger. It is worth noting that other factors such as stress, discomfort, and medication may also play a role in reducing appetite among patients with mono.

The Link Between Mono and Loss of Appetite

The Epstein-Barr virus, which causes mono, infects the cells of the immune system by binding to receptors on their surfaces. As the immune system attempts to fight off the virus, it releases various cytokines that cause inflammation and other symptoms such as fever and fatigue. Some of these cytokines may also trigger loss of appetite by interfering with the hormonal signals that regulate hunger and metabolism.

Moreover, the swelling of the lymph nodes, which commonly occurs in mono, may also contribute to a loss of appetite. Lymph nodes are responsible for filtering lymphatic fluid and removing bacteria, viruses, and other foreign substances from the body. Inflammation of these nodes, therefore, indicates the presence of an infection, and the body goes into a state of anorexia, where it reduces food intake to divert energy to fighting the infection.

Other Factors

While mono is a leading cause of loss of appetite, it is worth noting that other factors may also contribute to this condition. For instance, some medications used in treating mono such as antibiotics and antiviral drugs may cause nausea, which translates into a lack of interest in food. Stress, depression, and anxiety can also significantly affect an individual’s appetite, leading to a reduction in food intake.

Managing Loss of Appetite in Mono Patients

Managing loss of appetite in patients with mono is crucial in ensuring that they receive sufficient nutrients and energy to help fight the infection. Here are a few ways to manage loss of appetite in mono patients:

Eating Small, Frequent Meals

Encourage patients to eat small, frequent meals instead of large ones, as the latter may make them feel full faster. Smaller meals may, therefore, be easier to tolerate and digest, ensuring that they receive sufficient nutrients throughout the day.

Drinking Plenty of Fluids

Dehydration is a common problem among mono patients as they tend to take less fluids. Encouraging patients to take plenty of fluids such as water, fruit juice, and soups can prevent dehydration and help them to feel full, even when they do not have an appetite.

Foods to Avoid

Avoid giving patients foods that may further suppress their appetite, such as highly processed and sugary foods. Instead, provide them with nutrient-dense meals such as whole grains, fruits, vegetables, and lean protein.

Supplements and Nutrition Drinks

In severe cases, mono patients may need nutritional supplements to provide them with the necessary energy and nutrients. Supplements such as vitamins, minerals, and protein shakes can be beneficial in ensuring that patients receive sufficient nutrients to help fight the infection.


Loss of appetite is a common symptom among mono patients, and it can be managed by making dietary and lifestyle changes. By providing patients with nutrient-dense meals, encouraging them to eat small, frequent meals, and taking plenty of fluids, loss of appetite can be managed effectively. However, it is worth noting that other factors such as stress, medication, and underlying health conditions may also contribute to this condition. Therefore, it is crucial to seek professional advice when experiencing persistent loss of appetite.


  • Does mono always cause lack of appetite?

    No. Although it is a common symptom among mono patients, it is not a guaranteed symptom of the infection.

  • How long does loss of appetite last in mono patients?

    The duration of loss of appetite in mono patients varies depending on the severity of the infection. However, it typically lasts for only a few days to a week.

  • What should I give a mono patient who is experiencing loss of appetite?

    Provide them with small, frequent, nutrient-rich meals that are easy to digest. Encourage them to take plenty of fluids and avoid foods that may suppress their appetite further, such as highly processed and sugary foods.

  • Can loss of appetite in mono patients be treated with medication?

    There is no specific medication for treating loss of appetite in mono patients. However, a physician may recommend supplements or nutrition drinks in severe cases.


  • “Mononucleosis.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 17 Apr. 2021,

  • “Anorexia (Loss of Appetite).” Cleveland Clinic, 2021,

  • Bennett, E., et al. “Epstein-Barr virus: A pathogen inducing type I interferon-driven diseases.” Cytokine & Growth Factor Reviews, vol. 50, Jan. 2019, pp. 1-10, doi: 10.1016/j.cytogfr.2019.10.001.