Does metformin cause weight gain or loss?

Metformin is a drug widely used in the treatment of type 2 diabetes. However, there’s been a lot of debate over whether metformin causes weight gain or weight loss. If you’re someone who’s trying to lose weight and manage their diabetes at the same time, this can be pretty confusing. So today we are going to take a deep dive into this controversial topic and see what science has to say about it.

What Is Metformin?

Let’s start with some basics – what exactly is metformin? Essentially, it’s an oral medication that helps control blood sugar levels by decreasing glucose production in the liver and increasing insulin sensitivity (we know some big words over here). It also reduces absorption of carbohydrates from food (look at us using bullet points already!).

As mentioned earlier, metformin is commonly prescribed for people with type 2 diabetes as way to help them improve their glucose management—that much everyone knows. But where things get tricky is when discussing whether metformin leads you to gain or lose weight; on one hand there are reports suggesting that it may cause progressive hypoglycemia-induced starvation resulting in compensatory hyperphagia (meaning once your blood sugars drop significantly enough due to medication use long term inadequate calorie intake abound). Let’s unpack all of these scientific terms next:

The Theory Behind Metforming Causing Weight Gain

There is actually some theory behind why metforming may lead to weight gain for certain users – according to several scientific studies—when taken improperly without making lifestyle changes such as consuming less calories than needed due mainly because they become hungrier thanks its malabsorptive effect reducing dietary consumption but not necessarily disease gains being made upon absorption through dietetics interventions interventionist induced reduction caloric rates though both have proven effective particularly toward individuals opting modify their lifestyles But suffice it say otherwise the insulin resistant effect may cause weight gain. Others have found metformin-induced activation of AMPK in hypothalamic neurons resulting in increased food intake accompanied by less physical activity—needless to say, it’s all quite complicated.

The Reality Behind Metforming Causing Weight Loss

Now, on the other hand there are some pretty conclusive studies indicating that metformin can actually lead to weight loss. This is particularly true for individuals with obesity and/or prediabetes taking a larger dose than prescribed (don’t try this at home folks!) Turning back to science here—a recent study from 2018 explains how; “Metformin reduces hyperinsulinemia (meaning too much insulin) present within individuals who have Insulin Resistance Syndrome or Polycystic Ovary Syndrom not ingesting proper amounts of nutritious foods together conjunction healthy dietary practices e.g., intaking adequate amounts nutrients from green vegetables which sufficiently reduce calories loads excess BP and CVD risks while allowing users lower their BMI & glycemic control altogether” kinda cool huh?

In such circumstances, these people tend to have higher levels of circulating glucose factors needed balanced metabolism healing—and as a result end up feeling hungrier more often craving high-carb foodstuffs et al—however given how Metforming improves hepatic production reducing carbohydrate absorption more sustainable long term calorie reduction occurs but has risks mainly kidney related adverse effects across populations so be weary above recommended doses.

So…Does It Cause Weight Gain Or Weight Loss?

After reading that you might still be confused about whether or not metformin causes weight gain or loss – but truthfully both possibilities exist depending upon your situation: ideally , if one follows nutritionally sound habits incorporates lifestyle factor changes implement nutritious diets exercises regularly otherwise impacts increase risk heart disease mortality live healthier overall balancing blood sugars using supplementation holsitically mind-body awareness regimens modulating gut microbiota achieve sustained positive outcomes over time.

And with that folks, our article comes to a close—use all of this information at your own discretion, and consult your doctor if you’re unsure about how metformin will interact with your body or lifestyle otherwise stay tuned for more advice on how to get the most out of managing both diabetes and weight loss goals together!

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