Does histamine cause hair loss?

Are you wondering whether histamine causes hair loss? Well, the short answer is yes. However, just like everything else in life, things are not as simple as they appear on the surface.

To properly understand how histamine plays a part in hair loss, we need to delve into some basic biology concepts.

A Quick Biology Lesson

Histamine is a chemical compound that acts as a neurotransmitter in our body. It’s released by certain types of immune cells and plays an important role when it comes to various physiological functions such as:

  • Regulating blood flow
  • Stimulating gastric acid secretion
  • Controlling sleep-wake cycles
  • Promoting inflammation

When Histamine Goes Rogue

Have you ever taken antihistamines for allergies or other unpleasant symptoms? Antihistamines work by blocking the action of histamines so that they can’t bind to their receptors in your body.

However, there are times when excess levels of histamines can cause major disruptions and wreak havoc on multiple systems within the human body. The condition is called histamine intolerance, which occurs when there’s an overproduction of histamines or insufficient breakdown of it.

Symptoms include but not limited to:

  • Headaches/Migraines
  • Because excessive amounts of dopamine affects nociceptors (pain nerve fibers).

    As if anyone needs any more reasons to dread Mondays…

Symptoms Mechanisms
Mood swings Disruption between Serotonin->Melatonin cycle
Racing heart rate -> Palpitations Due increased norepinephrine signaling
Difficulty falling asleep -> Insomnia Excessive Dopaminergic disruption causing difficulty switching from Alerting system behavior mode

Additionally, elevated levels of histamines have been linked with various dermatological disorders such as eczema, urticaria/hives, rosacea and acne just to mention a few. The link between histamines and skin health brought about the question of whether histamine can cause hair loss.

Histamine Intolerance & Hair Loss

As we’ve mentioned earlier, an excess amount of histamines causes disruptions in multiple systems within our body. One way it affects our hair is by triggering the inflammation of follicles which leads to hair breakage and visible bald spots on your head. This condition is called alopecia areata.

Although alopecia areata is influenced by other factors like genetics or environmental changes, histamine intolerance can exacerbate its symptoms hence leading others to interpret that high levels of this neurotransmitter directly result in alopecia when treating AA’s root causes could stabilize individual HNMT (histaminergic n-methyl transferase) enzyme efficiency thereby minimizing damage if not preventing further complications indefinitely.

An alternative theory that presently lacks scientific backing (unlike evidence present for above), suggests constant activation/overactivation (be careful while using ‘over’)of mast cells due their inability to efficiently control immune-responses:

  • Under normal conditions – Mast Cells:

  • Trigger localized inflammatory response

  • Expel noxious foreign bodies out through swelling

However ‘when these responses become exaggerated, it results in chronic dysregulation thus reducing optimal blood flow thereby causing nutrient deficiency necessary for healthy follicle growth stimulating edges fray off; leaving the subjects` scalp more vulnerable than those who were otherwise unaffected’.

Unlike some genetic predispositions whose traits are passed down lineages from ancestors — such as Pattern Alopecia inherited differentially based on gene-expression along X-Chromosomes—treatment strategies towards targeting issues with hair health resulting from histaminergic disorders can often be resolved with elimination diet protocols.

The concept behind elimination diets simply revolve around identification/exclusion of potential allergenic agents (dairy, egg/milk products, process meat etc) from daily food intakes thus preventing possible trigger to immune cells that may activate hypersensitive response resulting in high histamine activity.

Moreover just like histamines can cause hair loss through alopecia areata caused by inflammation of follicles- replacing missing nutrients necessary for strong strands could increase resistance and reduce probability AGA symptoms eventually materializing ; These essential building block include Zinc, Iron Vitamin C, Manganese and Biotin also inclusive of mineral-rich plant based foods such as quinoa or kidney beans which contribute greatly towards healthy looking locks.

Histamine Intolerance Explained Further

Histamine intolerance is a condition that occurs when there’s an imbalance between the amount of histamines produced in your body versus the rate at which they’re broken down. Essentially imagine having too many dollars on hand than you usually would know how to spend within brief time without some kinda ‘budgeting constraints’/guidance.

This normally happens because our body has enzymes called DAO(Diamine oxidase) and HNMT(histaminergic n-methyltransferase) responsible for breaking down excess levels of histamines. Various factors can interfere with their function leading to elevated levels of histamines in our body including medication, alcohol intake or certain types of bacteria.. So much responsibility all seemingly centralized around two microscopic entities!!!

If you experience intolerance symptoms make sure seek medical help as it could indicate something more serious requiring immediate attention considering the range adverse reactions triggered under mostly benign circumstances.

What Can You Do About It?

The good news is that there’s plenty you can do about it! Here are a few things:

Reduce consumption High-Histimine Foods

Some common culprits associated with promoting disorders with overactive mastocytic immune system include but not limited to :

  • Processed/Bottled sauces [ketchup, mustard, balsamics] ,
  • Aged products like wine, cheese or beers
  • Preserved Meats
  • Foods containing added mono-sodium glutamate (MSG)


In conclusion, the answer to the question: does histamine cause hair loss? Is not that straightforward. However it is evident from certain histaminergic operative mechanisms within our body that can instigate loss of follicles.

It’s important to keep in mind that other factors may have a bigger role when it comes to hair loss than histamines alone including genetics and environmental triggers taking into account nutritional supplementation for optimal building blocks as needed. For those affected by AA with high levels of histamines who wish to promote healthy locks incorporating elimination diets under guidance of qualified personnel – reducing intake on meals popularly associated with high-histamine content helps stabilize levels until fundamental issues are resolved.
If you’re experiencing troubling symptoms, consult your doctor or seek medical advice from trusted sources.