Does doxycycline have acetaminophen in it?

What is doxycycline?

Doxycycline is an antibiotic in the tetracycline class used to treat a broad range of bacterial infections, such as acne, urinary tract infections, respiratory infections, and sexually transmitted infections. It works by preventing the growth and spread of bacteria.

What is acetaminophen?

Acetaminophen is a pain reliever and fever reducer medication. It belongs to the class of medicines called analgesics (pain relievers) and antipyretics (fever reducers). Acetaminophen is commonly sold under the trade name of Tylenol, and it is commonly used to treat headaches, muscle aches, backaches, arthritis, toothaches, colds, and fevers ‘

Does doxycycline have acetaminophen in it?

No, doxycycline does not have acetaminophen in it. Doxycycline and acetaminophen are two different medications. Doxycycline is an antibiotic, whereas acetaminophen is a pain reliever and fever reducer.

How does doxycycline work?

Doxycycline works by inhibiting the growth and replication of bacteria by preventing the production of essential proteins necessary for their survival. It interferes with the bacterial protein synthesis by binding to the ribosomes, thus preventing the bacteria from making new proteins. This process eventually leads to the death of the bacteria.

What are the side effects of doxycycline?

Like any other medication, doxycycline can cause side effects. The most common side effects include nausea, vomiting, diarrhea, stomach upset, headaches, dizziness, and skin sensitivity to sunlight. In rare cases, doxycycline can cause a severe allergic reaction, which may lead to anaphylaxis. If you experience any unusual symptoms while taking doxycycline, seek medical attention immediately.

How do I take doxycycline?

Doxycycline is available in various forms, such as tablets, capsules, and oral suspension. It is usually taken by mouth with a full glass of water, with or without food.

If you are taking the tablets or capsules, swallow them whole without crushing, chewing, or breaking them, followed by a full glass of water. It is recommended to take doxycycline with a meal or snack to avoid stomach upset.

The dosage and duration of treatment depend on your medical condition, age, weight, and response to treatment. Follow your doctor’s instructions carefully, and do not stop taking doxycycline unless your doctor tells you to.

Can I take doxycycline with other medications?

It is essential to inform your doctor about all the medications you are taking before starting doxycycline, as some drugs can interact with doxycycline, increasing the risk of side effects or reducing the effectiveness of the medication.

Doxycycline can interact with medications such as warfarin, antacids, iron supplements, birth control pills, and penicillin antibiotics.

Inform your doctor if you are taking any of these medications before starting doxycycline. Your doctor may adjust your dosage or monitor you more closely if you need to take both medications.

What Precautions should I take while taking doxycycline?

In addition to the potential side effects and drug interactions noted above, there are several other precautions to take while taking doxycycline.

First, avoid exposure to sunlight or artificial UV rays (tanning beds or sunlamps) while taking doxycycline, as it can increase skin sensitivity to the sun, leading to severe sunburn and skin rash.

Second, do not take doxycycline with milk or other dairy products, as they can interfere with the absorption of the medication, reducing its effectiveness.

Third, take doxycycline on an empty stomach if possible, as food can also affect its absorption. If you must take it with food to avoid stomach upset, wait for at least one hour before or two hours after a meal before taking doxycycline.

Fourth, avoid taking doxycycline before going to bed, as it can cause esophagitis (inflammation of the esophagus) if it remains in the esophagus while lying down. Take it with a full glass of water and remain upright for at least 30 minutes after taking it.

What should I do if I miss a dose?

If you miss a dose of doxycycline, take it as soon as you remember. If it is within a few hours of your next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to catch up. If you are unsure what to do, ask your doctor or pharmacist.

What should I do if I overdose?

In case of an overdose, contact your nearest emergency medical service or hospital immediately. Do not delay seeking medical attention, as an overdose of doxycycline can cause serious side effects, such as severe headache, blurred vision, vomiting, and seizures.


Doxycycline is an effective antibiotic used to treat a wide range of bacterial infections. It does not contain acetaminophen, which is a pain reliever and fever reducer. While taking doxycycline, it’s essential to follow your doctor’s instructions carefully, take all precautions, and report any unusual side effects.


Here are some common questions and answers related to the topic, “does doxycycline have acetaminophen in it?”

  • Q. Can I take doxycycline with acetaminophen?
  • A. Yes, doxycycline does not interact with acetaminophen. But talk to your doctor before taking any new medication.
  • Q. Can I drink alcohol while taking doxycycline?
  • A. It’s advisable to avoid alcohol while taking doxycycline because it can increase the risk of side effects such as dizziness, nausea, and stomach upset.
  • Q. Can doxycycline be used to treat viral infections?
  • A. No, doxycycline is only effective in treating bacterial infections, not viral infections such as the flu or cold.
  • Q. Can I take doxycycline during pregnancy?
  • A. Doxycycline should not be taken during pregnancy or while breastfeeding unless directed by your doctor as it can harm the developing fetus or nursing baby.


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  • Lammers, R. L. (2018). Acetaminophen toxicity. In StatPearls [Internet]. StatPearls Publishing.
  • Lodise Jr, T. P. (2014). Use of carbapenems, alone or in combination with other agents, for treatment of serious infections caused by resistant gram-negative bacteria. Clinical infectious diseases, 58(2), 274-284.
  • Skoog, T., van’t Hooft, J., & Andersson, R. (2017). The safety and efficacy of doxycycline in patients with community-acquired pneumonia/bronchitis. Journal of antimicrobial chemotherapy, 72(8), 2261-2267.