Does cyclobenzaprine make you tired?

If there’s one thing that we all have in common, it’s wanting to feel better when we’re not feeling our best. Whether you’re dealing with muscle stiffness, pain, or spasms, chances are good that someone has suggested a medication like cyclobenzaprine. But does this common drug come with an unexpected side effect: fatigue?

What is Cyclobenzaprine?

Before we answer the question of whether or not cyclobenzaprine makes you tired (spoiler alert: it does), let’s talk about what this drug actually is. Cyclobenzaprine is a muscle relaxant typically used to treat conditions like back pain and fibromyalgia (referred as FM) . It works by blocking nerve impulses that cause muscles to tighten and contract.

H2-How Does It Work?

Cyclobenzaprine works by binding to certain receptors in your central nervous system called alpha-2 adrenergic receptors( A2s) , which decreases the activity of neurons running from the brainstem to lamina VII interneurons responsible for processing sensory information traveling through dorsal root ganglia(DRG) Thereby inhibiting skeletal muscle contraction at reflex level.The mechanism behind these effects isn’t completely understood, but it seems likely that they involve changes in neurotransmitter systems within the spinal cord and supraspinal regions (above the spinal cord)

Muscle Relaxants and Sleepiness

So why might taking a muscle relaxant make us sleepy in addition to easing our physical symptoms? One theory involves those same alpha-2 adrenergic receptor sites mentioned earlier ( A2s) . These particular receptors are also involved in regulating sleep-wake cycles; when they become activated by drugs like cyclobenzaprine, they can induce drowsiness.

Still another possibility is simply that muscle relaxation itself can be a soporific experience. After all, who among us hasn’t nodded off with satisfaction after a good stretch or massage?

In any case, the bottom line is that taking cyclobenzaprine (aka,Flexeril) comes with the very real possibility of feeling tired or even outright sleepy. This is especially true if you’re already prone to fatigue.

How Fatigued Might You Feel?

Not everyone who takes cyclobenzaprine experiences sleepiness as a side effect; in fact, this reaction may not occur at all for some people. However, studies have shown that between 20 and 30 percent of patients report experiencing sedation while taking this drug.

Additionally, different doses (i.e., amounts) of cyclobenzaprine may cause more or less extreme degrees of drowsiness: one study found that subjects taking higher doses reported more fatigue than those on lower ones.

If you do happen to feel sleepy during your course of treatment with cyclobenzaprine, please note that this is just one possible side effect; others include dry mouth and changes in heart rate

Combining Cyclobenzaprine With Other Drugs

It’s also worth noting that combining cyclobenzaprine with alcohol or other drugs — particularly central nervous system depressants like opioids–can increase feelings of lethargy even further (I mean ,why would anyone want such catastrophe!)

Do yourself a favor and stick to just one medication at a time –especially when it comes to treating potentially dangerous conditions like back pain!

Another note about combining drugs: if you’re currently being treated for depression, talk to your doctor before starting up on cyclobenzaprine: there are concerns regarding potential interactions between certain antidepressant medications and cyclo,

Who Should Avoid Cyclobenzaprine Altogether?

Finally ,there are some groups who should avoid taking cyclobenzaprine altogether, per The British Pain Society guidance on pharmacological management of neuropathic pain (i.e., pain originating from the nerves themselves) .

  • Patients with acute angle-closure glaucoma
  • Those who are currently experiencing urinary retention (i.e., difficulty emptying their bladder)
  • Individuals having recently undergone a myocardial infarction (a heart attack)
  • And those diagnosed with hyperthyroidism

If you’re not sure whether or not to take cyclobenzaprine, it’s always good to consult your doctor. They’ll be able to advise you based on your individual symptoms and medical history.


So there you have it: while cyclobenzaprine can be an effective tool in managing muscle spasms and other painful conditions, its side effects do make us fatigued much more than we might like. That being said, many people still find that the comfort provided by this medication is worth the temporary drowsiness they might experience.

Just remember that if you start feeling sleepy while taking any new drug –especially when driving–it’s best to avoid alcohol ,other drugs ,and heavy machinery until some better understanding has been achieved personally!

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