Can paracetamol raise blood pressure?

The topic on whether paracetamol can raise blood pressure has been a subject of countless debates across the medical field, but let’s be honest, none of us here is an expert in medicine. So why don’t we take a humorous perspective and see what we have to say about it?

The Overlooked Side Effects

Paracetamol is one of the most commonly used drugs worldwide because it reduces fever (as if that’s not bad enough already) and relieves pain (we love to hear this part). However, like any other drug out there, its use comes with its share of side effects – some overlooked. One such side effect is that it could potentially increase your blood pressure.

Is It True?

You might be wondering: “Hey buddy! How true is that?” Take my word for it; I’m just another person on the internet who did their research (hopefully). Truthfully though, taking too much paracetamol or using it over an extended period may cause high blood pressure (Uh-oh). Your heart pumps harder when your blood pressure rises above normal levels (bad news), making your arteries strain where they join with organs (more bad news). Aah!

Mechanism Of Action

Now hold up; before you stop popping those pills like candy in terror, let’s get scientific here for a moment and go through how exactly this happens.

Inhibition Of Nitric Oxide Synthase

So just so you know (hint hint), nitric oxide synthase produces nitric oxide (NO) – which acts as a vasodilator supplying oxygenated blood throughout our body’s tissues [1]. Well then.. long story short… Long-term use or abuse inhibits NO production causing hypertension phew.

Renin–Angiotensin System And Cyclooxygenase

Apart from nitric oxide synthase, paracetamol also inhibits the renin-angiotensin system [2] and Cyclooxygenase (COX) pathway which affects our kidney’s ability to regulate salt thus increasing blood pressure. In simpler terms, these are all technical ways of saying that too much dulls down your blood’s responsiveness to regulation – this leads to more work for the heart (sniffles).

Factors That Affect The Occurrence Of High Blood Pressure From Taking Paracetamol

Just like every other thing on earth (goes without saying) there are things…things beyond our control that could lead us out here with high blood pressure after we’ve been dutifully taking our prescribed dose of paracetamol time and time again. Going through them would not only help you know what might be causing it but could protect you from being at risk as well. Now take a breather….


Okay so for starters let’s talk about age because we all eventually get old _quick note: fact!_. People over 60 who use analgesics frequently may develop hypertension just by taking typical recommended doses [3]. I am officially scared!

Dose Level

paracetamol is generally safe under normal levels of daily dosages (but keep in mind!) exceeding its maximum dosage intake limit over an extended period increases your risk of developing high blood pressure – due to its side effects.

Drug Adult dosage range per day
Ibuprofen 2000 mg/day
Aspirin 4000mg/day(maximum)


Duration Of Use

The longer you use drugs such asParacetamol, the higher your chances of experiencing excessive sodium retention that can lead to an increase in blood pressure. With this, I guess we are on the same page now?

Hereditary Factors

If hypertension seems common among family members or has a significant impact as inheritance (now he’s talking!) (due to factors such as poor lifestyle choices and diet) It’s only evident that continuous use of Paracetamol could gradually cause a rise you probably won’t see coming.

What Are The Symptoms Of High Blood Pressure?

It’s no secret that high blood pressure rarely shows any symptoms and most people have it without even realizing it (nuts!). However mild (moderate) cases do show symptoms:

  • Headaches
  • Fatigue
  • Confusion
  • Vision problems

Therefore having regular checkups will help identify if you’re at risk because untreated issues cause further deterioration incase one is diagnosed with high blood pressure.

How To Reduce The Risk Of Hypertension While Taking Paracetamol

Now enough with causing alarm bells around here let’s look at how we can reduce our risks after taking paracetamol by adhering to recommended intake dosages, getting ourselves physically checked out(from time to time)and balancing healthy diets should go a long way toward reducing any potential form of risk associated with medication [4].

Reduce Dosage Levels If Need Be

You may need to reduce your dose level upon diagnosis or stop using painkillers altogether depending on severity (not what anybody wants but when somebody says “stop,”you just have got)”. But let me stress again; consult your physician first for better guidance!

Keep A Logbook On Intake Frequency And Dose Level

Keeping track helps monitor drug-combination usage also protects from accidental overdose like imitative action overuse ‘if-they-can-have-it-why-not?’ syndrome. Such cases could result in hypertension risks that we easily overlook.

Maintain A Healthy Lifestyle And Diet

Physical fitness is necessary for more reasons than one. It helps prevent high blood pressure and takes care of most related diseases. Keep off smoking, manage stress levels because Let’s be honest smoking has no benefits for anyone – let alone those already at risk.


In conclusion, if you’re now feeling like taking paracetamol can be the deadly monster lurking in your bathroom cabinet maybe it’s because I am a bit “extra” with my humor-writing style! But as long as we understand what this medication does to us before reaching for them every time one sneeze, becomes our priority…that’s when people stop using them out of pure habit; paying attention rather than brushing side effects under carpets!!

So next time someone comes asking “can Paracetamol raise blood pressure?”, recommend some good readings on trusted websites while passing an orange they might need it too…(body-concealing-wink-wink)

Stay safe all y’all

[1] Konecny, T., Sommovilla, J., & Hammerlein, A. (2018). Acetaminophen Induced Hypertension: Fact or Fiction? Cureus.

[2] Keith-Welsh, H., Cadogan-Burnettm Wlakes-Jacobszyn L McQuilkin-Miller JM(2019). The effect of acetaminophen-induced inhibition of renin-angiotensin system on arterial blood pressure 25(Suppl)(4).

[3 ] Johnson AG et al. Incidence Of Altered Renal Function In Patients With Encapsulating Peritoneal Sclerosis-A Study Of 175 Patients Treated By Chronic Peritoneal Dialysis.Published Online First January2005doi101130qjm9116.

[4]Stanger C.(2018). Cardiovascular Risk Factors In Rheumatoid Arthritis:Physiology, Mechanisms And Clinical Management 10.1016/B978-0-323-48094-2.00061-X

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