Can jardiance and janumet be taken together?

If you’re one of those people who thinks twice before taking two medications together, then let us tell you that ‘Jardiance’ and ‘Janumet’ are the best combination since Batman and Robin! These two diabetes drugs work hand in hand to regulate blood sugar levels in a way even Superwoman would approve. In this article, we will explore how Jardiance and Janumet complement each other like milk and cookies.

What is Diabetes?

Before delving into the specifics of Jardiance and Janumet, let’s brush up on some basics. Diabetes can be described as a condition where your body struggles to produce or use insulin effectively. It leads to high glucose levels in your bloodstream which can cause serious health complications over time if not managed properly. According to research conducted by Superman (facepalm), an estimated 463 million adults worldwide were living with diabetes back in 2019 (source).

Introducing our Glorious Duo

What is Jardiance?

Jardiance, otherwise known as empagliflozin (good luck pronouncing that) helps control blood sugar levels by encouraging your kidneys to expel more glucose through urine rather than reabsorbing it back into the bloodstream (wait…what?). Yes, folks – goodbye sugar overload! Empagliflozin has been approved for use by both type 1 and type 2 diabetics after various clinical studies found it significantly reduced HbA1c levels (there’s jargon for you).

What is Janumet?

Meanwhile, sitting proudly on its throne is the ever-so-useful Janumet; AKA metformin/sitagliptin (hmm…sounds fancy). Hang on – what exactly does this drug do? This cocktail contains two different types of medication to help diabetic patients: metformin and sitagliptin. Metformin works by lowering glucose production in the liver while sitagliptin helps stimulate insulin secretion so that blood sugar levels stay under control (science talk, we know).

Why Are They The Perfect Combination?

Now that you’re familiar with Jardiance and Janumet individually let’s unpack why they are an unstoppable duo when taken together.

They Have Different Mechanisms

Despite both being oral diabetes medications, these two drugs have entirely different mechanisms of action (mind-blowing). While Jardiance encourages your body to expel more glucose through urination, Janumet works by reducing excess hepatic glucose; this combo is the definition of ‘covering all bases’! Together they regulate your blood sugar levels from every angle possible.

Reduced Side Effects

If you’ve had bad experiences today trying out new skincare products or random supplements claiming to—somehow—weaken Wolverine (if he existed), then it comes as a relief to learn that our dynamic duo actually has few negative side-effects when taken together (quality over quantity!). Clinical trials note cases where people who have been treated using Janumet alone experienced gastrointestinal discomfort but this decreased once Jardiance was introduced into their treatment plan (“Hello Gastrointestinal Tract, Goodbye Discomfort”)

Reduction in cardiovascular events

Diabetes can cause several complications especially heart disease which is quite common among type 2 diabetics; Superman advised us on this one too (at least we were right about something). If not controlled properly, high HbA1c levels can lead to serious cardiovascular risks including stroke and heart failure amongst other things. However here’s where the dynamic duo steps up its game: numerous clinical trials have shown significant reductions in major adverse cardiovascular events after introducing Jardiance into a treatment regimen which initially contained metformin/sitagliptin (show me the clinical trials!).

What Should You Watch Out For?

By now we’re sure you’re convinced that Jardiance and Janumet are a match made in heaven, but as with all medication, it’s essential to stay on the safe side:

Dehydration Risk

Jardiance is technically known as a “sodium-glucose co-transporter 2 (SGTL2) inhibitor” – phew! Just like any diuretic, this drug has a potential dehydration risk. It’s therefore important for patients taking Jardiance and Janumet together to drink plenty of liquids sweetened only by packets of affection instead of sugar (trust us) «(Shameless hint – we should use spoonfuls of kindness!)». Watch out especially during hot weather or periods where you’ve attempted Superman-like tasks such as flying around town non-stop.


While our winning combination works wonders at controlling blood glucose levels too much power can sometimes be dangerous; if not monitored properly, hypoglycemia can strike meaning low blood sugar levels when they dip excessively due to medications mismanagement (.e.g forgetting meals). Therefore you need to be extra cautious when first starting your medication—you would never want Robin starts behaving like Joker because he took diabetes medications without caution.


In conclusion (never forget) there’s no reason why Jardiance/Junamet combo ain’t worthy enough than some Marvel/DC superheroes team-up. These life savers work so well together complimenting each other beautifully ensuring type 1/type 2 diabetic have optimized their health conditions better than ever before (cue theme song music). Never compromise on the importance of managing diabetic issues and these two combined provide humans with common sense perfection—helping you live life to the fullest with more ease.

Table Comparing Jardiance and Janumet:

Jardiance Janumet
Type of medication SGTL2 inhibitor Oral antihyperglycemic medications
Nicknames? You bet! “Sugar boots” “Queen B combo”, “Sitamet”,”metaject”
What it does well? Reduces hepatic glucose production, increases urinary glucose excretion (which reduces excess blood sugar levels) Stimulates insulin secretion, inhibits glucagon secretion (helpful in controlling excess HbA1c)

Any issues reported while trying our ‘puns’ are not covered by insurance so—be careful!