Can i take suboxone 24 hours after methadone?

Are you one of those people who can’t seem to decide when it is okay to take Suboxone after methadone? Whether you’re a seasoned user or just starting your journey, this guide will help shine some light on the situation.

The Battle Between Two Titans

Methadone and Suboxone are two popular prescription drugs used to treat addiction. While they may have different mechanisms of action and active ingredients, both share the common purpose of relieving withdrawal symptoms from opioid dependence.

Understanding Methadone

Methadone is an opioid medication that binds to pain receptors in the brain and central nervous system (CNS). It was initially developed during World War II due to a shortage of morphine for medicated soldiers but has since become widely used as part of an addiction treatment program.

Understanding Suboxone

Suboxone is a combination drug containing buprenorphine and naloxone. Buprenorphine is an opioid partial agonist which helps alleviate cravings without producing the same level of euphoria as pure opioids. Naloxone, on the other hand, blocks opioid receptors preventing any chance of abuse or overdose.

When Is It Okay To Take Them Together?

The million-dollar question – should you take Subxome soon after taking methadonbe? While there’s no black-and-white answer, here are some factors you should consider:

  1. Dosage
  2. Time frame
  3. Personal suitability


Firstly before considering dosages: Always seek advice from your doctor before combining these medications in order not suffer adverse effects like seizures, severe dizziness or difficulty breathing (which could lead to death).

It all depends on how much methadonbe that patient takes everyday i.e their maintenance dose; As higher doses are given over longer periods of time it leads to greater tolerance and dependence.

The general rule is to wait for at least 24 hours after your last dose of methadone before taking Suboxone. This is because methadone has a longer half-life than other opioids – this means the drug stays in the system for extended periods, potentially causing an overdose if taken too soon after another medication containing an opioid that covers substantially less duration (such as suboxone).

Time Frame

When you first start taking these medications or switch from one to another, there’s always a transition period where you may experience withdrawal symptoms like diarrhea and muscle pain, among others. During this period, it is important not only to find the right dosage but also allow enough time between switching drugs.

The preferred method of transitioning involves gradual tapering off with both types administered together via a doctor scheme. A standard detox regimen should require no more than four days under medical supervision—otherwise can end up going through hard withdrawal which could lead back into addiction tendencies according to studies . In some cases (although very rare), healthcare professionals may choose to use them concurrently at smaller dosages until patients have become stable on their maintenance therapy – this requires professional expertise and guidance since doing so without prescriptive guidelines could be fatal.

Personal Suitability

Aside from dosages and timelines choosing when patient needs either medication depends on certain conditions such as liver function test results–patients prescribed buprenorphine alone have shown increase levels in their transaminase enzymes compared with those using formulation containing naloxene; hence persons with current or past liver problems are often encouraged not dwell beyond suitable prescription point without consulting doctors (which is cautionary in many situations).

Other Alternatives To Consider: Winding Down Dosage On Methadonbe

There are several ways patients can transition from methadonbe usage:

1) Continue taking Methandrane moderately allowing system to naturally transition over time,
2) Make use of fast tapers in which the patient reduces intake one day at a time, or another intensive alternative where doses are increased then decreased afterwards. There has been no evidence that intense treatments would lead to better outcomes however.


Methadone and Suboxone are both great medications used for addiction treatment; however, combining them can be risky if not managed properly by your doctor. While it is acceptable practice to switch from one medication to the other when properly overseen by practitioner (the sequences of courses should never coincide), both drugs may not sync with everyone’s unique physiology so having individual responses will inform doctors trying out other possible alternatives on what course would work best in gaining an effective outcome whilst reducing potential harm.

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