Can i take melatonin with gabapentin?

When it comes to medication, the more you know about what’s going into your body, the better off you are. But let’s face it: sometimes things get confusing. Like when you’re trying to figure out if melatonin and gabapentin can be taken together without any nasty interactions.

Understanding Melatonin and Gabapentin

First of all, let’s talk basics. What are melatonin and gabapentin? Here’s a quick rundown:


  • A natural hormone produced by your pineal gland that regulates sleep-wake cycles
  • Sometimes used as a supplement to help with insomnia or jet lag
  • Generally considered safe in low doses

Fun fact: Did you know that some foods naturally contain melatonin? Tart cherries, for example, are one such food.


  • An anticonvulsant medication originally developed to treat epilepsy
  • Also used for nerve pain (such as neuropathy) and conditions like restless leg syndrome or anxiety disorders
  • Can have side effects like dizziness or drowsiness

Now that we’ve got the basics down, let’s answer the big question.

The Short Answer: Yes

(with caveats)

You can take melatonin with gabapentin without causing harm – at least according to current research – but there are some important things to keep in mind.

Caveat #1: Talk To Your Doctor First

Before starting either of these medications (or any others), it’s always best practice to check in with your healthcare provider first. They’ll be able to assess your individual situation and offer advice tailored specifically for you.

Pro tip: Always be honest with your healthcare provider about all medications (prescription or over-the-counter), supplements, and illicit drugsyou may be taking concurrently.

I won’t go full ‘mom-mode’ about this, but seriously: be honest with your doctor. They’re there to help you, not judge you.

Caveat #2: Dosage is Important

The potential for drug interactions or side effects tends to increase as the dosage of a medication increases. With both melatonin and gabapentin, lower doses are generally considered safer than higher ones.

If you regularly take these medications, make sure that the dosages you’re taking aren’t putting you at risk for unwanted symptoms like dizziness or confusion (common with higher dose gabapentin).

Pro tip: Keep a medication journal where you can track when and how much of each medication/supplement/drug/alien elixir (just kidding)you’re taking.

Caveat #3: Side Effects Might Appear

While both melatonin and gabapentin are generally safe in low doses, we don’t know everything. Some people may experience side effects when combining them; others might not notice any difference after adding one to their existing regimen.

Potential side effects commonly associated with either melatonin or gabapentin include:
– Dizziness
– Drowsiness
– Mood swings
– Headaches
– Gastrointestinal distress
Fancy term for feeling nauseous/throwing up/diarrhea)

Keep an eye out for new symptoms emerging in your body/mind. But try not to become paranoid!

Melatonin vs Gabapentin Side Effects

(i.e. nausea or vomiting)

Also includes stomach cramps/pain/diarrhea in some cases.

May occur if taking large doses of melatonin; rare in lower dose supplements.

td>Fairly common, especially at higher dosages.Avoid alcohol! ; don’t drink alcohol while taking gabapentin.

## Caveat #4: Melatonin is Not Regulated By the FDA

At this time,melatonin is considered a supplement, not strictly regulated by the U.S. Food and Drug Administration (FDA) like most prescription drugs are.

The same applies to other natural supplements – Kratom, CBD oil, turmeric, etc. (a firm that buys popular health foods/supplements/vitamins/etc off the shelves for testing) discovered that many brands of melatonin don’t contain as much active ingredient as advertised, contain more impurities (not always harmful; but gross), or have contaminated with dangerous levels of other drugs by mistake.

Pro tip: Make sure the brand you’re purchasing has undergone thorough testing before trusting! Check out ConsumerLab and similar agencies for a low-down on specific items.

## Caveat #5: Interactions With Other Medications

While melatonin and gabapentin are typically well-tolerated on their own, they may interact negatively with certain medications. Here are just a few examples:

### Melatonin
– Blood thinners like warfarin
– Immunosuppressants like cyclosporine
– Birth control pills

### Gabapentin
– Antacids that contain magnesium or aluminum
– Opioid painkillers
( Strong suggestion to avoid combining opioids with any CNS depressants – an individual can end up unconscious quickly)

When in doubt, consult ya doc.

Hopefully this article has helped answer your questions about taking melatonin and gabapentin together. While it’s generally considered safe to do so if done correctly, there are important factors to keep in mind – dosages being one key consideration — before adding these supplements/medicines to your daily routine.

If after reading all this you still have questions or concerns? You guessed it:

Stay sleepy yet alert out there!

Copyright © 2023 Dane101 | Last updated: 08 Jun, 2023
| 125 queries. 0.610 seconds.
Side Effect Melatonin Gabapentin
Drowsiness/fatigue Most common side effect  
Dizziness Less common Most common side effect
Mood swings/nightmares/me thinks I’m an Egyptian Pharaoh Rare Not specifically listed
But can interact with other medications and cause mood changes One theoretical example, not a proven side effect!
Gastrointestinal distress