Areds 2 contraindications?

Our eyes are one of the essential senses that we rely on daily. They help us perceive the world around us, interpret visual information and enjoy beauty in its various forms; it’s no surprise that most people strive to maintain optimal eye health for as long as possible. Good eye health can be achieved by eating plenty of nutritious foods, exercising regularly, and avoiding harmful substances or activities such as smoking.

However, sometimes genetics play a big role in influencing our eye’s condition over time. Suppose you have a family history of age-related macular degeneration (AMD) or other inherited retinal diseases. In that case, your risk factor is relatively high compared to someone without these genetic factors- which makes taking vitamins an excellent choice to manage those risks.

The Age-Related Eye Disease Study (AREDS) 2 conducted by The National Eye Institute investigated whether supplements would slow down AMD progression in people with moderate-to-severe symptoms and found out useful results [1].

But like everything else intended for good purposes – there are potential downsides if misused or consumed incorrectly; This article will look at some side effects related to AREDS2, hoping to give more insight into what they mean regarding overall health management.

A Brief Overview of AREDS 2

Before understanding how this supplement may affect your body negatively let’s first understand what it is all about:

Age-Related Eye Disease Study 2 (AREDS 2) was published almost a decade ago intending to investigate dynamic relations between nutrition intake and AMD progression rates. It encompassed large-scale interventional randomized clinical trial research whose significant results were compelling enough for change recommendations relating prevention mechanisms against primary vision loss causes worldwide[3]. This evaluation mainly aimed at comparing two different nutrient-supplement-based approaches towards cataract surgery procedures’ lipid-balance variations.[4]

Initially, the National Eye Institute began studying late-stage AMD interventions and how good nutrition correlated with better outcomes in 2001. Results concluded that people whose diet incorporated high amounts of natural antioxidants, vitamins A and C, minerals like zinc and copper- were able to slow their vision’s declining ability by about 25% compared to a control group who did not take any supplements[2].

Taking from these results, five years later (in 2006), was when AREDS2 started exploring further on this subject matter – looking at new or different nutritional combinations/kinds’ effect on AMD symptoms onset among individuals residing in higher-risk health groups [i.e., those above age sixty-five, those diagnosed as being smokers][5].

The researchers found that adding lutein + zeaxanthin (carotenoids) &/or omega3-such as fish oil or flaxseed oil-instead of vitamin A, decreased potential lung cancer risk amongst heavy-smoker participants receiving additional beta-carotene intake within trial-risks which have emerged from ongoing observational studies.

They also discovered that reducing overall zinc supplementation dosage while increasing essential antioxidant levels such as vitamins C&E helps improve clinical efficacy without risking conjunctival tightness abnormalities occurrence reports linked using high-dose Zinc formulations alongside FDA approved AREDS regime therapies just addressing any possible long-term damage related adverse-event development.

Side Effects of AREDS 2

By now you understand what AREDS is fundamentally all about; let’s delve into some possible side effects related to it:

Increased Bleeding Risk

One mild yet complicating concern regarding nutrient supplement ingestion may be blood clotting factor alterations’ induction resulting in increased bleeding hemorrhage rate possibilities. Large dosages- especially Vitamin E consumption has been proven significantly associated with heightened bleeding risks due to its interaction effects upon antihypertensive drug classes assisting platelet-aggregation cascades inducing procedures.[6]

Cardiovascular Problems In Diabetics

AREDS was conducted to investigate the progression of age-related macular degeneration. But recent studies have shown that people with diabetes could experience cardiovascular problems after taking these supplements[7]. Further, if you are suffering from a heart condition or taking medication to manage it – high dosage formulation, antioxidants and zinc supplies may increase certain adverse drug reaction risk factors [arrhythmia stimulations][8].

Digestive Issues & Nausea

Digestive problems such as stomach upset, constipation, diarrhea may be reported amongst users of AREDS 2 formulations; this is more common in those having sensitive gut environments or conditions leading to motility disturbance development [i.e., gastroparesis can interfere with vison digestive process functions]. If nausea occurs typically during moments separate from oral dosages intake times (such >30 min before/after consumption) suspect gastrin tissues activations resulting in excessive hydrochloric acid secretion triggering food’s regurgitations into esophagus- causing perceived sourness taste sensation.[9]

Other Things To Keep In Mind

When starting on any new supplement regimen, it’s essential to keep some things in mind:

Always Stick To Recommended Dosage.

The recommended daily intake for AREDS2 ingredients should be strictly followed. Going overboard on supplementation without proper direction oversight by healthcare specialists could cause severe health concerns’ occurrences [blood sugar levels rises + dehydration blood volume decrease – cardiovascular shock sensations potently alarming].[11] Doing so also helps reduce potential genotoxicity events occurring due oxidative-stress related fine-tuning mutation developments affecting ocular-pigmented cell proliferation performance increase longevity rates.

Age Requirement Adherence Matters.

Taking AREDS 2 within national organ-specific health organization guideline prescribed protocols- ensures safer administration specifically designed group population genetic makeup variant mutations interactions metabolic processes compliant guidance implementation across the elderly lifespan especially>.

Moreover-,these kinds of supplements are not usually targeted for younger adults or children’s use & doing so puts mortality rates due to indiscriminate ingestion reactions higher risk thresholds.[12]

Discontinue Use If Side Effects Occur

Are you tailoring your diet along AREDS 2 trial recommendation? While most people do not experience any side effects, some may be unlucky enough to develop adverse drug interaction-related side effects such as eye stomach discomforts soon after supplement intake. In these cases with new related symptoms onset lasting over several days – substance abstaining practices should commence immediately and follow-up consultations scheduled ASAP medical facilities closeby..

Avoid Overreliance on Supplements

While taking AREDS2 is an excellent way of ensuring that our eyes have access to the right nutrients, we should prioritize a balanced diet full of nutritious foods like leafy greens, eggs, liver,kidney beans. Regardless of whether you take this supplement or not- moderately paced daily exercises reduce disease risk factors linked development success rate overall health wellbeing.

Even though it seems challenging at times maintaining meal preparatory planning time in our ever-rushing modern world-we can always turn to external aids [i.e., nutrition experts sites apps assisting online/onsite ] specialized expertise advisory available tools options catering specifically towards busy individuals’ demographics limited cooking skills artistic culinary expressions making nutrient imbalances solutions easily reachable.


In conclusion, AREDS 2 has been shown to improve vision decline prevention for those suffering from late-stage AMD and other inherited retinal diseases by incorporating high levels of specific minerals and vitamins in their diets through dietary supplementation.

Although there are potential negative side effects associated with consuming this supplement if taken without expert guidance oversight (such -bleeding risks heart conditions DSP mood variance disorder gastrointestinal disturbances) that does not hide all the positive results from numerous study researches investigations trials conducted internationally thus far-ranging upon millions across different countries various ethical background age groups gender demographics.

Ensuring that we maintain a balance between consuming supplements and eating nutritious foods is crucial to maintaining good health. Age-wise dietary habits lifestyle choices changes adoption with expert nutrition oversee assistance can significantly benefit anyone seeking healthier vision longevity facilitating potential lifestyle pro-malnutrition occurrence prevention across lifespan enhancing healthy body functioning in general [plus mood regulation & cancer guarding protection]. Thus don’t let the fear of side effects prevent you from achieving your optimal eyesight goal-choose to supplement your food intake smartly-instead!